{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:30:20Z","timestamp":1759336220661},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,26]],"date-time":"2015-03-26T00:00:00Z","timestamp":1427328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Endoplasmic reticulum aminopeptidase 1 (ERAP1) has been confirmed to be associated with ankylosing spondylitis (AS) in Caucasian. However, whether they are associated with AS in East Asian population remains unidentified. We investigated this relationship by a new Chinese case\u2013control study and a meta\u2010analysis of published series. 368 cases and 460 controls were recruited in the Chinese case\u2013control study. Genotyping was completed using the chip\u2010based matrix\u2010assisted laser desorption ionization time\u2010of\u2010flight mass spectrometry. Allelic associations were analysed using contingency tables. In the meta\u2010analysis, up to 2748 cases and 2774 controls from seven different studies and the new Chinese study were combined using <jats:sc>Review Manager<\/jats:sc> software version 5.1.1. Mantel\u2013Haenszel or Inverse Variance test was used to calculate fixed or random\u2010effects pooled <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>s. In the new Chinese study, strong association with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> was observed for marker rs10050860, rs27434 and rs1065407 at <jats:italic>P<\/jats:italic> value of &lt;0.001. Moderate association was observed for rs30187 at <jats:italic>P<\/jats:italic> value of &lt;0.01, while no association was observed for rs27044 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.37) and rs2287987 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.23). The meta\u2010analysis showed that rs27037 and rs30187 were strongly associated with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.00001). Significant association was also observed for rs27434 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001). No association was shown for rs27044 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.70). We concluded that <jats:styled-content style=\"fixed-case\">ERAP<\/jats:styled-content>1 variants are associated with <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> in East Asian population, indicating a common pathogenic mechanism for <jats:styled-content style=\"fixed-case\">AS<\/jats:styled-content> in East Asians and Caucasians.<\/jats:p>","DOI":"10.1111\/iji.12196","type":"journal-article","created":{"date-parts":[[2015,3,27]],"date-time":"2015-03-27T22:11:49Z","timestamp":1427494309000},"page":"168-173","source":"Crossref","is-referenced-by-count":10,"title":["<scp>ERAP<\/scp>1 variants are associated with ankylosing spondylitis in East Asian population: a new Chinese case\u2013control study and meta\u2010analysis of published series"],"prefix":"10.1111","volume":"42","author":[{"given":"C.","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Spinal Surgery Tianjin Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery Tianjin Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328362042f"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2013.06.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm242"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100652"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60635-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem269"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.17"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2011.01067.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.105296"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24933"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.873"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1286"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100019"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200347"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp371"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.09.012"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2012.11.002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101262108"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780270401"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24467"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2021"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090806"},{"key":"e_1_2_7_25_1","first-page":"800","article-title":"Association of IL23R and ERAP1 genes with ankylosing spondylitis in a Portuguese population","volume":"27","author":"Pimentel\u2010Santos F.M.","year":"2009","journal-title":"Clinical and Experimental Rheumatology"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.513"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2013.819855"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker229"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3855"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-1994-8"},{"key":"e_1_2_7_31_1","first-page":"127","article-title":"Association of polymorphisms in the ERAP1 gene with ankylosing spondylitis in the Han Chinese population","volume":"49","author":"Y Xia L.C.W.","year":"2011","journal-title":"J Shandong University (Health sciences)"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.32607\/20758251-2010-2-3-72-77"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12196","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:54:31Z","timestamp":1696308871000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,26]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1111\/iji.12196"],"URL":"https:\/\/doi.org\/10.1111\/iji.12196","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,26]]}}}