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Intrathyroid lymphocytic infiltration may lead to progressive destruction of thyroid tissue and consequently to hypothyroidism. Many studies in different populations have shown association between vitamin D receptor (<jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>) gene polymorphisms and various autoimmune diseases, including <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>. The study included 44 female patients (mean age\u00a0\u00b1\u00a0standard deviation 38\u00a0\u00b1\u00a05.4) with <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ashimoto's thyroiditis and 32 healthy age\u2010matched, sex\u2010matched and geographically matched controls without personal history of autoimmune and endocrine diseases. Genomic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was isolated from peripheral blood\u2013<jats:styled-content style=\"fixed-case\">EDTA<\/jats:styled-content>, and the target <jats:italic><jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content><\/jats:italic> gene was genotyped by <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content> technique after <jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>\u2010<jats:italic><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ok<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content><\/jats:italic> (rs2228570), <jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>\u2010<jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>paI<\/jats:italic> (rs7975232) and <jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>\u2010<jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aq<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content><\/jats:italic> (rs731236) restriction enzymes digestion. We used <jats:sc>spss<\/jats:sc> 20.0 integrated software for data analysis and found a significant difference in the genotype distribution of <jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>\u2010<jats:italic><jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ok<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content><\/jats:italic> polymorphism between patients with <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> and controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.009). For <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>pa<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>aq<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content><\/jats:italic>, we observed a higher frequency of variant allele in patients with <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>, which was not significantly different compared to control women (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). The current first and preliminary results identified the association between <jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\"><jats:italic>FokI<\/jats:italic><\/jats:styled-content> gene polymorphism and Hashimoto's thyroiditis in Serbian population. Results need to be supported by further investigations that define haplotype patterns for <jats:styled-content style=\"fixed-case\">VDR<\/jats:styled-content> gene polymorphisms in a larger group of <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content> patients of both sexes.<\/jats:p>","DOI":"10.1111\/iji.12199","type":"journal-article","created":{"date-parts":[[2015,3,30]],"date-time":"2015-03-30T05:23:26Z","timestamp":1427693006000},"page":"190-194","source":"Crossref","is-referenced-by-count":17,"title":["Association between <scp><i>FokI<\/i><\/scp>,<scp><i>ApaI<\/i><\/scp> and <scp><i>TaqI<\/i> RFLP<\/scp> polymorphisms in <scp>VDR<\/scp> gene and <scp>H<\/scp>ashimoto's thyroiditis: preliminary data from female patients in <scp>S<\/scp>erbia"],"prefix":"10.1111","volume":"42","author":[{"given":"J.","family":"Djurovic","sequence":"first","affiliation":[{"name":"Institute of Forensic Medicine Faculty of Medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Stojkovic","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine Faculty of Medicine University of Belgrade Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Faculty of Medicine Cumhuriyet University Sivas Turkey"},{"name":"Department of Medical Genetics Faculty of Medicine Canakkale Onsekiz Mart University Canakkale Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Silan","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Faculty of Medicine Canakkale Onsekiz Mart University Canakkale Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Akurut","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Faculty of Medicine 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