{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:22:47Z","timestamp":1789586567579,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Systemic Sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) is a systemic autoimmune disorder, with ambiguous pathogenesis. Genetic and environmental factors were proved to be correlated with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c aetiology. Single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in cytokine genes can alter the structure and function of the cytokines and consequently may increase the susceptibility to a specific disease. In this study, we investigated <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s of the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 gene cluster in Iranian <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients. We obtained blood samples from 170 <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients and 213 healthy individuals. Cytokine genotyping results were obtained by polymerase chain reaction with sequence\u2010specific primers (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SSP<\/jats:styled-content>). <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101A<\/jats:italic> rs1800587, <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101B<\/jats:italic> rs1143634 and <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101R1<\/jats:italic> rs2234650 were evaluated for <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> study. The frequency of the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101B<\/jats:italic> rs1143634 <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> genotype was significantly lower in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients compared to the controls (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.584; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.385\u20130.886; <jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a00.023), so we propose that <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> genotype of this allele might be protective. According to our haplotype analysis, <jats:styled-content style=\"fixed-case\">CCC<\/jats:styled-content> haplotype frequency is higher in the control group compared to <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.575; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.176\u20132.111; <jats:italic>P\u2010<\/jats:italic>value\u00a0=\u00a00.008) and in contrast, <jats:styled-content style=\"fixed-case\">CTC<\/jats:styled-content> haplotype frequency is lower in the control group compared to <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.152; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a00.047\u20130.484; <jats:italic>P\u2010<\/jats:italic>value\u00a0=\u00a00.002), so they might decrease and increase the susceptibility of having <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c, respectively. In addition, we reported two significant diplotypes frequency differences among <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients and healthy individuals. It is highly important that there is not much resemblance between the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 gene cluster polymorphism in different populations, so we can indicate that <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s may play critical roles when they are combined with other genetic and environmental factors.<\/jats:p>","DOI":"10.1111\/iji.12212","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T04:58:30Z","timestamp":1443502710000},"page":"423-427","source":"Crossref","is-referenced-by-count":24,"title":["<i><scp>IL<\/scp>\u20101<scp>A<\/scp><\/i> rs1800587, <i><scp>IL<\/scp>\u20101<scp>B<\/scp><\/i> rs1143634 and <i><scp>IL<\/scp>\u20101<scp>R<\/scp>1<\/i> rs2234650 polymorphisms in <scp>I<\/scp>ranian patients with systemic sclerosis"],"prefix":"10.1111","volume":"42","author":[{"given":"S.","family":"Abtahi","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology University of Tehran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Farazmand","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology University of Tehran Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Rheumatology Research Center Shariati Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ashraf\u2010Ganjouei","sequence":"additional","affiliation":[{"name":"Rheumatology Research Center Shariati Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Javinani","sequence":"additional","affiliation":[{"name":"Rheumatology Research Center Shariati Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Nazari","sequence":"additional","affiliation":[{"name":"Rheumatology Research Center Shariati Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kavosi","sequence":"additional","affiliation":[{"name":"Rheumatology Research Center Shariati Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Amirzargar","sequence":"additional","affiliation":[{"name":"Molecular Immunology Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Rheumatology Research Center Shariati Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Gharibdoost","sequence":"additional","affiliation":[{"name":"Rheumatology Research Center Shariati Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230510"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.suppl_1.i60"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-516-9_2"},{"key":"e_1_2_5_5_1","first-page":"298","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"1","author":"Benjamini Y.","year":"1995","journal-title":"Journal of the Royal Statistical Society, Series B"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23836"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.269.2.C443"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.000950"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.05.003"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/301817"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1684\/ecn.2014.0350","article-title":"Determination of IL\u201023 receptor gene polymorphism in Iranian patients with ankylosing spondylitis","volume":"25","author":"Daryabor G.","year":"2014","journal-title":"European Cytokine Network"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/exmp.2002.2435"},{"key":"e_1_2_5_13_1","first-page":"81","article-title":"Interleukin 1alpha single\u2010nucleotide polymorphism associated with systemic sclerosis","volume":"31","author":"Hutyrova B.","year":"2004","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10736"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339710791330768"},{"key":"e_1_2_5_16_1","first-page":"13","article-title":"DNA extraction and quantitation of forensic samples using the phenol\u2010chloroform method and real\u2010time PCR","volume":"297","author":"Kochl S.","year":"2005","journal-title":"Methods in Molecular Biology"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2009.33"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00331.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/anr.1780320809"},{"key":"e_1_2_5_20_1","first-page":"997","article-title":"Association of polymorphisms in the IL1B and IL2 genes with susceptibility and severity of systemic sclerosis","volume":"34","author":"Mattuzzi S.","year":"2007","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380210"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1992.tb01480.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2013.160"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cr.7290272"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1635114100"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12212","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:23:00Z","timestamp":1696288980000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,28]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/iji.12212"],"URL":"https:\/\/doi.org\/10.1111\/iji.12212","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,28]]}}}