{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:56:56Z","timestamp":1772891816083,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T00:00:00Z","timestamp":1434585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Deputy, Hamadan University of Medical Sciences.","award":["16.82.34"],"award-info":[{"award-number":["16.82.34"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2015,8]]},"abstract":"Summary<\/jats:title>This study aimed to determine the HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1\/HLA<\/jats:styled-content>\u2010DQB<\/jats:styled-content>1 susceptibility and protection pattern for type 1 diabetes (T1D) in a population from Hamadan, north\u2010west of Iran. A total of 133 patients with T1D were tested for HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1 and HLA<\/jats:styled-content>\u2010DQB<\/jats:styled-content>1 alleles using PCR<\/jats:styled-content>\u2010SSP<\/jats:styled-content> compared to 100 ethnic\u2010matched healthy controls. Alleles and haplotypes frequencies were compared between both groups. The most susceptible alleles for disease were HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1*03:01, DRB<\/jats:styled-content>1*04:02, DQB<\/jats:styled-content>1*02:01 and DQB<\/jats:styled-content>1*03:02, and protective alleles were HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1*07:01, *11:01, *13:01, *14:01 and DRB<\/jats:styled-content>1*15 and HLA<\/jats:styled-content>\u2010DQB<\/jats:styled-content>1*06:01, *06:02 and *06:03. Haplotype analysis revealed that patients with T1D had higher frequencies of DRB<\/jats:styled-content>1*03:01\u2013DQB<\/jats:styled-content>1*02:01 (OR<\/jats:styled-content>\u00a0=\u00a04.86, P\u00a0<\/jats:italic><\u00a010\u22127<\/jats:sup>) and DRB<\/jats:styled-content>1*04:02\u2013DQB<\/jats:styled-content>1*03:02 (OR<\/jats:styled-content>\u00a0=\u00a09.93, P\u00a0<\/jats:italic><\u00a010\u22127<\/jats:sup>) and lower frequencies of DRB<\/jats:styled-content>1*07:01\u2013DQB<\/jats:styled-content>1*02:01 (P<\/jats:italic>\u00a0=\u00a00.0005), DRB<\/jats:styled-content>1*11:01\u2013DQB<\/jats:styled-content>1*03:01 (P<\/jats:italic>\u00a0=\u00a00.001), DRB<\/jats:styled-content>1*13:01\u2013DQB<\/jats:styled-content>1*06:03 (P<\/jats:italic>\u00a0=\u00a00.002) and DRB<\/jats:styled-content>1*15\u2013DQB<\/jats:styled-content>1*06:01 (P<\/jats:italic>\u00a0=\u00a00.001) haplotypes compared to healthy controls. Heterozygote combination of both susceptible haplotypes (DR<\/jats:styled-content>3\/DR<\/jats:styled-content>4) confers the highest risk for T1D (RR<\/jats:styled-content>\u00a0=\u00a018.80, P<\/jats:italic>\u00a0=\u00a04\u00a0\u00d7\u00a010\u22125<\/jats:sup>). Additionally, patients with homozygote diplotype, DR<\/jats:styled-content>3\/DR<\/jats:styled-content>3 and DR<\/jats:styled-content>4\/DR<\/jats:styled-content>4, showed a similar risk with less extent to heterozygote combination (P<\/jats:italic>\u00a0=\u00a00.0004 and P<\/jats:italic>\u00a0=\u00a00.01, respectively). Our findings not only confirm earlier reports from Iranians but also are in line with Caucasians and partly with Asians and some African patients with T1D. Remarkable differences were the identification of DRB<\/jats:styled-content>1*04:01\u2013DQB<\/jats:styled-content>1*03:02, DRB<\/jats:styled-content>1*07:01\u2013DQB<\/jats:styled-content>1*03:03 and DRB<\/jats:styled-content>1*16\u2013DQB<\/jats:styled-content>1*05:02 as neutral and DRB<\/jats:styled-content>1*13:01\u2013DQB<\/jats:styled-content>1*06:03 as the most protective haplotypes in this study.<\/jats:p>","DOI":"10.1111\/iji.12216","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T05:08:49Z","timestamp":1434690529000},"page":"279-286","source":"Crossref","is-referenced-by-count":11,"title":["HLA<\/scp> class II<\/scp> susceptibility pattern for type 1 diabetes (T1D) in an Iranian population"],"prefix":"10.1111","volume":"42","author":[{"given":"J.","family":"Kiani","sequence":"first","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine School of Medicine Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hajilooi","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Furst","sequence":"additional","affiliation":[{"name":"Department of Transplantation Immunology Institute for Clinical Transfusion Medicine and Immunogenetics Ulm University of Ulm & German Red Cross Blood Donor Services Baden\u2010W\u00fcrttemberg\u2010Hessia Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Shahryari\u2010Hesami","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kowsarifard","sequence":"additional","affiliation":[{"name":"Division of Endocrinology Department of Internal Medicine School of Medicine Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zamani","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Solgi","sequence":"additional","affiliation":[{"name":"Department of Immunology School of Medicine Hamadan University of Medical Sciences Hamadan Iran"},{"name":"Psoriasis Research Center Department of Dermatology Farshchian Hospital Hamadan University of Medical Sciences Hamadan 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