{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:12:18Z","timestamp":1784848338164,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,18]],"date-time":"2015-09-18T00:00:00Z","timestamp":1442534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tehran University of Medical Sciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Recurrent aphthous stomatitis (<jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>) is a common painful, ulcerative oral inflammatory disorder with unknown aetiology. Immune system and aberrant cytokine cascade deemed to be critical in outbreaks of <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> ulcers. Interleukin\u20101 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101) and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 are the most potent pro\u2010inflammatory cytokines. Single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 genes can affect the secretion of these cytokines. The aim of this study was to investigate the association between <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101 in Iranian subjects with minor <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>. Genomic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was obtained from 64 Iranian patients with <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b1<\/jats:italic> C \u2212889 T, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic> C \u2212511 T, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101<jats:italic>\u03b2<\/jats:italic> C +3962 T, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101R C pst\u2010I 1970 T, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101Ra C Mspa\u2010I11100 T, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 C \u2212174 G and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 A nt +565 G polymorphisms were determined using polymerase chain reaction with sequence\u2010specific primers (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SSP<\/jats:styled-content>). The frequency of C \u2212174 C genotype in the patients group was significantly different from the healthy control. No other significant differences were found in genotype and alleles frequencies between the two groups. These results indicate that certain <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 gene at position \u2212174 which located in promoter have association with predisposition of individuals to <jats:styled-content style=\"fixed-case\">RAS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/iji.12228","type":"journal-article","created":{"date-parts":[[2015,9,19]],"date-time":"2015-09-19T04:25:52Z","timestamp":1442636752000},"page":"428-431","source":"Crossref","is-referenced-by-count":29,"title":["Association study of interleukin\u20101 family and interleukin\u20106 gene single nucleotide polymorphisms in recurrent aphthous stomatitis"],"prefix":"10.1111","volume":"42","author":[{"given":"S.","family":"Najafi","sequence":"first","affiliation":[{"name":"Dental Research Center School of Dentistry Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Oral Medicine School of Dentistry Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yousefi","sequence":"additional","affiliation":[{"name":"Research Center for Immunodeficiencies Children's Medical Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Department of Oral Medicine Dental Branch Tehran Azad University Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mohammadzadeh","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine School of Dentistry Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Z.","family":"Bidoki","sequence":"additional","affiliation":[{"name":"Molecular Immunology Research Center; and Department of Immunology School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Firouze Moqadam","sequence":"additional","affiliation":[{"name":"Molecular Medicine Research Center Hormozgan University of Medical Sciences Bandar Abbas Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Farhadi","sequence":"additional","affiliation":[{"name":"Hematology Department School of Allied Medical Science Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. A.","family":"Amirzargar","sequence":"additional","affiliation":[{"name":"Molecular Immunology Research Center; and Department of Immunology School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Research Center for Immunodeficiencies Children's Medical Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Molecular Immunology Research Center; and Department of Immunology School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Universal Scientific Education and Research Network (USERN) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2004.08.001"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2005.00502.x"},{"key":"e_1_2_7_4_1","first-page":"84","article-title":"Cytokine single nucleotide polymorphisms in Iranian patients with pulmonary tuberculosis","volume":"17","author":"Amirzargar A.A.","year":"2006","journal-title":"European Cytokine Network"},{"key":"e_1_2_7_5_1","first-page":"104","article-title":"Cytokine single nucleotide polymorphisms in Iranian populations","volume":"19","author":"Amirzargar A.A.","year":"2008","journal-title":"European Cytokine Network"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363882"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.7.827"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2012.01134.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3800"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2629"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.08.008"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071059"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-3571-6"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04535.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364393"},{"key":"e_1_2_7_16_1","first-page":"95","article-title":"Recurrent aphthous stomatitis","volume":"31","author":"Ship J.A.","year":"2000","journal-title":"Quintessence International"},{"key":"e_1_2_7_17_1","first-page":"1","article-title":"An exploration of point, annual, and lifetime prevalence in characterizing recurrent aphthous stomatitis","volume":"12","author":"Shulman J.D.","year":"2004","journal-title":"Oral Diseases"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.4666"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12228","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:23:06Z","timestamp":1696288986000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,18]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1111\/iji.12228"],"URL":"https:\/\/doi.org\/10.1111\/iji.12228","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,18]]}}}