{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:57:22Z","timestamp":1790506642405,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T00:00:00Z","timestamp":1447459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270871"],"award-info":[{"award-number":["81270871"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471004"],"award-info":[{"award-number":["81471004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Summary<\/jats:title>Interleukin 33 (IL<\/jats:styled-content>33) \/ ST<\/jats:styled-content>2 pathway and ST<\/jats:styled-content>2\u2010interlukin18 receptor1\u2010interlukin18 receptor accessory protein (ST<\/jats:styled-content>2\u2010IL<\/jats:styled-content>18R1\u2010IL<\/jats:styled-content>18RAP<\/jats:styled-content>) gene cluster have been involved in many autoimmune diseases but few report in autoimmune thyroid diseases (AITD<\/jats:styled-content>). In this study, we investigated whether polymorphisms of IL<\/jats:styled-content>33, ST<\/jats:styled-content>2, IL<\/jats:styled-content>18R1, and IL<\/jats:styled-content>18RAP<\/jats:styled-content> are associated with Graves' disease (GD<\/jats:styled-content>) and Hashimoto's thyroiditis (HT<\/jats:styled-content>), two major forms of AITD<\/jats:styled-content>, among a Chinese population. A total of 11 SNP<\/jats:styled-content>s were explored in a case\u2013control study including 417 patients with GD<\/jats:styled-content>, 250 HT<\/jats:styled-content> patients and 301 controls, including rs1929992, rs10975519, rs10208293, rs6543116, rs1041973, rs3732127, rs11465597, rs1035130, rs2293225, rs1035127, rs917997 of IL<\/jats:styled-content> 33, ST<\/jats:styled-content>2\u2010IL<\/jats:styled-content>18R1\u2010IL<\/jats:styled-content>18RAP<\/jats:styled-content> gene cluster. Genotyping of these SNP<\/jats:styled-content>s was performed using matrix\u2010assisted laser desorption \/ ionization\u2013time\u2010of\u2010flight mass spectrometer (MALDI<\/jats:styled-content>\u2010TOF<\/jats:styled-content>\u2010MS<\/jats:styled-content>) platform from Sequenom. The frequencies of allele A and AA<\/jats:styled-content>+AG<\/jats:styled-content> genotype of rs6543116 (ST<\/jats:styled-content>2) in HT<\/jats:styled-content> patients were significantly increased compared with those of the controls (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.029\/0.021, OR<\/jats:styled-content>\u00a0<\/jats:italic>=\u00a0<\/jats:italic>1.31\/1.62). And in another SNP<\/jats:styled-content> rs917997, AA<\/jats:styled-content>+AG<\/jats:styled-content> genotype presented an increased frequency in HT<\/jats:styled-content> subjects compared with controls (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.046, OR<\/jats:styled-content>\u00a0=\u00a01.53). Furthermore, the haplotype GAGCCCG<\/jats:styled-content> from ST<\/jats:styled-content>2\u2010IL<\/jats:styled-content>18R1\u2010IL<\/jats:styled-content>18RAP<\/jats:styled-content> gene cluster (rs6543116, rs1041973, rs1035130, rs3732127, rs1035127, rs2293225, rs917997) was associated with increased susceptibility to GD<\/jats:styled-content> with an OR<\/jats:styled-content><\/jats:italic> of 2.03 (P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.022, 95% CI<\/jats:styled-content>\u00a0<\/jats:italic>=\u00a0<\/jats:italic>1.07\u20133.86). Some SNP<\/jats:styled-content>s of ST<\/jats:styled-content>2\u2010IL<\/jats:styled-content>18R1\u2010IL<\/jats:styled-content>18RAP<\/jats:styled-content> gene cluster might increase the risk of susceptibility of HT<\/jats:styled-content> and GD<\/jats:styled-content> in Chinese Han population.<\/jats:p>","DOI":"10.1111\/iji.12240","type":"journal-article","created":{"date-parts":[[2015,11,14]],"date-time":"2015-11-14T07:12:55Z","timestamp":1447485175000},"page":"18-24","source":"Crossref","is-referenced-by-count":16,"title":["Polymorphisms of ST<\/scp>2\u2010IL<\/scp>18R1\u2010IL<\/scp>18RAP<\/scp> gene cluster: a new risk for autoimmune thyroid diseases"],"prefix":"10.1111","volume":"43","author":[{"given":"X.","family":"Wang","sequence":"first","affiliation":[{"name":"Clinical Research Center The First Affiliated Hospital of Medical School Xi'an Jiaotong University Shaanxi China"},{"name":"Department of Endocrinology Jinshan Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. F.","family":"Zhu","sequence":"additional","affiliation":[{"name":"Clinical Research Center The First Affiliated Hospital of Medical School Xi'an Jiaotong University Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. M.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Jinshan Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Jinshan Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. S.","family":"Muhali","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Jinshan Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. J.","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Jinshan Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Jinshan Hospital of Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920210793360907"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.175"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-10-98"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2009.23.3303"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4149\/endo_2013_02_57"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v25.i2.10"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8731"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/stke.3902007pe31"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0602313"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2009.02096.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.472"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M704916200"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2058"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2011.26.9.1132"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.102"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.489"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5090"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2000.6269"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2012.03.016"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2692"},{"key":"e_1_2_7_22_1","first-page":"Ab138","article-title":"Novel IL33 gene polymorphisms associated with asthma are associated with resistance to Schistosoma mansoni","volume":"2","author":"Masuko H.","year":"2013","journal-title":"The Journal of Allergy and Clinical Immunology"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar1497"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-012-8283-9"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.10.5777"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep402"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(00)00015-0"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2014.09.011"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2008.03114.x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.014"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.09.015"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi323"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807917"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq078"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.5.787"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801898105"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2008.03.016"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2008.67"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12240","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T04:02:00Z","timestamp":1695700920000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,14]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/iji.12240"],"URL":"https:\/\/doi.org\/10.1111\/iji.12240","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,14]]}}}