{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:27:53Z","timestamp":1759048073662},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T00:00:00Z","timestamp":1450396800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"departmental resources"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Three novel HLA\u2010Class II alleles, DRB1*03:112, DQB1*03:02:16 and DQB1*03:139, are described with predicted bearing haplotypes of A*02:01, B*40:01, C*03:04, DRB1*03:112, DQB1*02:01; A*23:01, B*15:01, C*03:03, DRB1*04:01, DQB1*03:02:16 and\u00a0A*01:01, B*44:02, C*05:01\/03, DRB1*04:01, DQB1*03:139. Serological tests showed that the DRB1*03:112 and DQB1*03:139 specificities failed to react as expected with some well\u2010documented monoclonal antibodies. Subsequent examination of published HLA\u2010Class II epitopes and inspection of amino acid motifs suggested that epitopes exist that include the positions of their single substitutions (F31C between DRB1*03:01:01:01 and DRB1*03:112, and R48P between DQB1*03:01:01:01 and DQB1*03:139 specificities). This suggests that the reactivity of the monoclonal antibodies used was dependent on these epitopes and that their loss from these rare allele products resulted in their aberrant serology. The new alleles were found after the sequence\u2010based typing of 32\u00a0530 random UK European routine blood donors suggesting that each has a maximum carriage frequency of 0.0031% in the blood donor population resident in Wales.<\/jats:p>","DOI":"10.1111\/iji.12244","type":"journal-article","created":{"date-parts":[[2015,12,19]],"date-time":"2015-12-19T05:44:55Z","timestamp":1450503895000},"page":"40-44","source":"Crossref","is-referenced-by-count":3,"title":["Immunogenetics of three novel HLA\u2010Class II alleles: DRB1*03:112, DQB1*03:02:16 and DQB1*03:139"],"prefix":"10.1111","volume":"43","author":[{"given":"J.","family":"Street","sequence":"first","affiliation":[{"name":"Welsh Transplantation and Immunogenetics Laboratory Welsh Blood Service Pontyclun Wales UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Welsh Transplantation and Immunogenetics Laboratory Welsh Blood Service Pontyclun Wales UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Lemin","sequence":"additional","affiliation":[{"name":"Welsh Transplantation and Immunogenetics Laboratory Welsh Blood Service Pontyclun Wales UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Welsh Transplantation and Immunogenetics Laboratory Welsh Blood Service Pontyclun Wales UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Darke","sequence":"additional","affiliation":[{"name":"Welsh Transplantation and Immunogenetics Laboratory Welsh Blood Service Pontyclun Wales UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2011.01730.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/oso\/9780199633647.003.0003","volume-title":"Histocompatibility Testing: A Practical Approach","author":"Darke C.","year":"1993"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000019057"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.08.001"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.10.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12017"},{"key":"e_1_2_7_8_1","first-page":"295","volume-title":"Clinical Transplants 2009","author":"El\u2010Awar N.","year":"2010"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.05.013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/378457a0"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2007.05.015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(97)01093-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01466.x"},{"key":"e_1_2_7_14_1","unstructured":"Pepperall J. McGregor M. Johnson J. Street J.&Darke C.(2014)Sequence\u2010based HLA typing of young donors on the Welsh Bone Marrow Donor Registry (WBMDR). Presented at the 10th Annual International Donor Registry Conference London May 2014."},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1161"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12551"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12244","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12244","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T06:29:27Z","timestamp":1718260167000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,18]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/iji.12244"],"URL":"https:\/\/doi.org\/10.1111\/iji.12244","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,18]]}}}