{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T07:51:11Z","timestamp":1783151471949,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T00:00:00Z","timestamp":1454630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We investigated the allele and haplotype frequencies of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1 loci in Dalian Chinese Han population using blood samples of unrelated marrow donors who live in Dalian. The genetic relationship between Dalian and different regions worldwide was further explored based on <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> status of different populations. A total of 14\u00a0529 samples were genotyped at 2\u2010digit level only by sequence\u2010specific oligonucleotide and sequence\u2010based typing methods. Allele frequencies of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1 were calculated by the direct counting method. Haplotype frequencies and linkage disequilibrium (<jats:styled-content style=\"fixed-case\">LD<\/jats:styled-content>) values were calculated by the maximum likelihood method. <jats:italic>F<\/jats:italic><jats:sub>ST<\/jats:sub> values were calculated by allele frequency data of each locus. Phylogeny tree of Nei's <jats:styled-content style=\"fixed-case\"><jats:italic>D<\/jats:italic><jats:sub><jats:italic>A<\/jats:italic><\/jats:sub><\/jats:styled-content> genetic distances was constructed by the <jats:styled-content style=\"fixed-case\">UPGMA<\/jats:styled-content> method. <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A*02 was the most frequent allele at <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A locus followed by A*11 and A*24. Alleles at <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B locus ranked in decreasing order by frequency were B*40, B*15 and B*13. The three highest frequency alleles were <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*15, <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*09 and <jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*12 at <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1 locus. A*30\u2010B*13\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*07 was the most frequent three\u2010locus haplotype. For the population relationships, Dalian had a relative close genetic relationship with Liaoning and Yantai\u2010Weihai and a relative distant genetic relationship with Australia. The information obtained in this study may provide useful information for anthropological studies, for disease\u2010association studies and helping bone marrow transplantation patients to search <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010matched donors.<\/jats:p>","DOI":"10.1111\/iji.12248","type":"journal-article","created":{"date-parts":[[2016,2,5]],"date-time":"2016-02-05T05:58:16Z","timestamp":1454651896000},"page":"79-85","source":"Crossref","is-referenced-by-count":7,"title":["<scp>HLA<\/scp>\u2010A, <scp>HLA<\/scp>\u2010B, <scp>HLA<\/scp>\u2010<scp>DRB<\/scp>1 allele and haplotype frequencies of 14\u00a0529 Chinese Han bone marrow donors living in Dalian, China"],"prefix":"10.1111","volume":"43","author":[{"given":"L. N.","family":"Shao","sequence":"first","affiliation":[{"name":"Dalian Blood Center Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. T.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Dalian Blood Center Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. J.","family":"Yu","sequence":"additional","affiliation":[{"name":"Dalian Blood Center Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Dalian Blood Center Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Duan","sequence":"additional","affiliation":[{"name":"Dalian Blood Center Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Z.","family":"Pan","sequence":"additional","affiliation":[{"name":"Dalian Blood Center Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Wang","sequence":"additional","affiliation":[{"name":"Dalian Blood Center Dalian Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Hu","sequence":"additional","affiliation":[{"name":"The School of Life Science and Technology Harbin Institute of Technology Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"35","article-title":"The frequencies of HLA\u2010A, B, DRB1 allels and Haplotype and their distribution among haemopoietic stem cell of Han volunteers in Jilin bone marrow library of China","volume":"23","author":"Chen L.","year":"2010","journal-title":"Chinese Journal of Blood Transfusion"},{"key":"e_1_2_7_3_1","first-page":"5","article-title":"Allele and haplotype frequencies for the loci HLA\u2010A, B and DRB1 in 2,210 Jiangxi Chinese Han unrelated bone marrow donors","volume":"8","author":"Cheng L.H.","year":"2006","journal-title":"Journal of Clinical Transfusion and Laboratory Medicine"},{"key":"e_1_2_7_4_1","first-page":"810","article-title":"The distribution of HLA\u2010A, B, DRB1 alleles and haplotypes Guangzhou blood donors","volume":"26","author":"Ding H.Q.","year":"2010","journal-title":"Zhong Guo Mian Yi Xue Za Zhi"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2007.04.006"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-0998.2010.02847.x"},{"key":"e_1_2_7_7_1","first-page":"164","article-title":"PHYLIP \u2010 Phylogeny Inference Package (Version 3.2)","volume":"5","author":"Felsenstein J.","year":"1989","journal-title":"Cladistics"},{"key":"e_1_2_7_8_1","first-page":"161","article-title":"Characteristic and distribution of human leukocyte antigen\u2010A, B, DRB1 genes and haplotypes in Anhui Chinese Han population","volume":"7","author":"Gao S.Q.","year":"2005","journal-title":"Journal of Clinical Transfusion and Laboratory Medicine"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532296"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009073431006"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200009143431106"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.05.013"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2005.00386.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0093082"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.61.01.023"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1086\/282771"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02300753"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2011.01029.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1093\/genetics\/105.3.767","article-title":"Estimation\u00a0of the coancestry coefficient: basis for a\u00a0short\u2010term\u00a0genetic\u00a0distance","volume":"105","author":"Reynolds J.","year":"1983","journal-title":"Genetics"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks949"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2011.02669.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3325\/cmj.2008.4.476"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12064"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3343\/kjlm.2008.28.6.465"},{"key":"e_1_2_7_25_1","first-page":"108","article-title":"Study of characterization of polymorphyism of the HLA haplotype in hunan district population","volume":"8","author":"Xie Y.B.","year":"2006","journal-title":"Journal of Clinical Transfusion and Laboratory Medicine"},{"key":"e_1_2_7_26_1","first-page":"65","article-title":"Incidence\u00a0survey\u00a0of\u00a0leukemia\u00a0in\u00a0China","volume":"6","author":"Yang C.","year":"1991","journal-title":"Chinese Medical Sciences Journal"},{"key":"e_1_2_7_27_1","first-page":"930","article-title":"Gene frequency and haplotype of HLA\u2010A, B, DRB1 in donors from Henan branch of China marrow donor program","volume":"42","author":"Yang R.Y.","year":"2007","journal-title":"Journal of Zhengzhou University (Medical Sciences)"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12007"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2010.00930.x"},{"key":"e_1_2_7_30_1","first-page":"229","article-title":"Analysis of HLA\u2010A, B, and DRB1 polymorphism and genetic distance in Han population living in Yantai and Weihai regions of\u00a0Shandong\u00a0province","volume":"29","author":"Zhang Y.","year":"2012","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"e_1_2_7_31_1","first-page":"5","article-title":"Analysis of the genetic polymorphism of HLA\u2010A, B, DRB1 alleles in Chinese marrow donor program registries from Yunnan province branch","volume":"13","author":"Zhu X.M.","year":"2011","journal-title":"Journal of Clinical Transfusion and Laboratory Medicine"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12248","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T11:15:00Z","timestamp":1695726900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,5]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/iji.12248"],"URL":"https:\/\/doi.org\/10.1111\/iji.12248","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,5]]}}}