{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T23:02:18Z","timestamp":1715986938068},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T00:00:00Z","timestamp":1461283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The cause of prostate cancer (<jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>), one of the most common cancers found among ageing men, remains unclear, but genetic predisposition is believed to play a major role in its aetiology. The aim of the study was to examine <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> genes polymorphism and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> polymorphisms in <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> development. Patients diagnosed with <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> (<jats:italic>N<\/jats:italic>\u00a0=\u00a0113) and 150 healthy individuals were tested for <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010A, <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1 genes and for <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>a, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>b and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>d microsatellites. The comparison of patients and controls revealed a positive association of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*12, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>a2 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>b5, and a negative association of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*13 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>b4 with <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>. A division of patients into groups according to age, pre\u2010operative <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content> level, Gleason score (<jats:styled-content style=\"fixed-case\">GS<\/jats:styled-content>) and involvement of prostatic capsule, seminal vesicles or bladder neck and perineural invasion of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> demonstrated the following: a positive correlation of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*12 and a negative correlation of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1*13 with younger patients (&lt;65\u00a0years), <jats:styled-content style=\"fixed-case\">GS<\/jats:styled-content>\u00a0&gt;\u00a07 and the positive association of prostatic capsule, seminal vesicles, bladder neck and perineural invasion of <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content>;<jats:styled-content style=\"fixed-case\"> TNF<\/jats:styled-content>b4 allele's negative association with older patients displaying higher <jats:styled-content style=\"fixed-case\">PSA<\/jats:styled-content> levels, higher <jats:styled-content style=\"fixed-case\">GS<\/jats:styled-content> and positive surrounding tissue involvement; positive association of <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>b5 allele for both older and younger patients. Investigation of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> genes and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> microsatellites demonstrated a possible role of <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">DRB<\/jats:styled-content>1 and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> regions in <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> aetiology.<\/jats:p>","DOI":"10.1111\/iji.12262","type":"journal-article","created":{"date-parts":[[2016,4,22]],"date-time":"2016-04-22T22:03:20Z","timestamp":1461362600000},"page":"143-150","source":"Crossref","is-referenced-by-count":2,"title":["The possible role of the tumour necrosis factor polymorphisms and human leucocyte antigens in the development of prostate cancer"],"prefix":"10.1111","volume":"43","author":[{"given":"K.","family":"Stingl Jankovic","sequence":"first","affiliation":[{"name":"Clinical Unit for Tissue Typing Clinical Department for Transfusion Medicine and Transplantation Biology University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hudolin","sequence":"additional","affiliation":[{"name":"Clinical Department of Urology University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Kastelan","sequence":"additional","affiliation":[{"name":"Clinical Department of Urology University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Zunec","sequence":"additional","affiliation":[{"name":"Clinical Unit for Tissue Typing Clinical Department for Transfusion Medicine and Transplantation Biology University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Grubic","sequence":"additional","affiliation":[{"name":"Clinical Unit for Tissue Typing Clinical Department for Transfusion Medicine and Transplantation Biology University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,22]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"IMGT\/HLA databasehttp:\/\/www.ebi.ac.uk\/ipd\/imgt\/hla\/[Accessed on 15 June 2013]."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr802"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007126219791"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2628"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2008.273"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20694"},{"key":"e_1_2_6_8_1","unstructured":"Ferlay J. 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