{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T01:46:01Z","timestamp":1774921561512,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Chongqing Municipal Natural Science Foundation","doi-asserted-by":"crossref","award":["20021889"],"award-info":[{"award-number":["20021889"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Science and Technology Fund of Chongqing Municipal Health Bureau","award":["07-2-062"],"award-info":[{"award-number":["07-2-062"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Interleukin\u201021 (IL\u201021), as a multifunctional cytokine, plays an important role in many diseases, such as cancer, inflammatory and autoimmune diseases. We aimed to investigate the relationship between polymorphisms of IL\u201021 gene and susceptibility of hepatitis B virus (HBV)\u2010related hepatocellular carcinoma (HCC) in a Chinese population. Studied subjects were divided into three groups: 100 patients with HBV\u2010related HCC, 115 patients with chronic HBV infection and 127 healthy controls. Genomic DNA was isolated from peripheral blood, and the polymerase chain reaction\u2013ligase detection reaction (PCR\u2010LDR) method was used to genotype the SNPs (rs2221903, rs907715 and rs12508721) within IL\u201021 gene. Our results showed that IL\u201021 polymorphisms were associated with the risk of HCC and chronic HBV infection when compared with healthy controls. The rs2221903A\/G AG genotype was associated with a higher risk of chronic HBV infection when compared with healthy controls [AG versus AA\u00a0+\u00a0GG, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.036, OR\u00a0=\u00a01.898, 95%CI\u00a0=\u00a01.038\u20133.471]. The rs12508721C\/T TT genotype was related with a lower risk of chronic HBV infection and HBV\u2010related HCC than in healthy controls [TT versus CT\u00a0+\u00a0CC, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.026, OR\u00a0=\u00a00.451, 95%CI\u00a0=\u00a00.221\u20130.920; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.049, OR\u00a0=\u00a00.482, 95%CI\u00a0=\u00a00.231\u20131.005]. No significant difference in the genotype and allele distrubutions of rs907715G\/A SNP was observed in the HBV\u2010related HCC group, chronic HBV\u2010infected group and the healthy control group when compared to each other. Our findings suggest that the rs12508721T\/C and rs2221903A\/G polymorphisms of IL\u201021 gene are associated with the susceptibility of HBV\u2010related HCC and chronic HBV infection. The genetic variant may in fact cause protection against the HBV\u2010related HCC. However, the function in these SNPs of IL\u201021 gene needs to clarify the mechanisms involved in the pathogenesis of HBV\u2010related HCC further.<\/jats:p>","DOI":"10.1111\/iji.12263","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T06:35:19Z","timestamp":1461825319000},"page":"151-158","source":"Crossref","is-referenced-by-count":11,"title":["Association between interleukin\u201021 gene polymorphisms (rs12508721) and HBV\u2010related hepatocellular carcinoma"],"prefix":"10.1111","volume":"43","author":[{"given":"Q. X.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. Q.","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. J.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64980-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.5.2827"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-012-9497-7"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.12.7251"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2013.166"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2013.0007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02507.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.01.005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9935-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2012.966"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20538"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2009.01382.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2008.02.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090316"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.19122"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-939755"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-8-28"},{"key":"e_1_2_7_20_1","first-page":"469","article-title":"Association of interleukin 18 gene promoter polymorphisms with HBV recurrence after liver transplantation in Han Chinese population","volume":"11","author":"Wu L.","year":"2011","journal-title":"Hepatitis Monthly"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.12.050"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i14.4232"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2401-1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2014.1707"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12263","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T11:03:50Z","timestamp":1695726230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,28]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/iji.12263"],"URL":"https:\/\/doi.org\/10.1111\/iji.12263","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,28]]}}}