{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:33:51Z","timestamp":1759336431534},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Departmental resources"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*14:53 was found in a<jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>European normal blood donor prior to registration on the Welsh Bone Marrow Donor Registry. It differs from B*14:13 by one base (103G&gt;T) in exon 2 resulting in a substitution of alanine (A) in B*14:13 to serine (S) in B*14:53. Unique among current<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B*14 alleles, B*14:53 and B*14:13 share a motif of 59 bases between positions 361 and 419 in exon 3. This motif is present in numerous<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B alleles the commonest overall being B*08:01, suggesting that both B*14:53 and B*14:13 arose from intralocus gene conversion events with B*08:01. Thus, B*14:53 probably arose from B*14:01:01 (which has<jats:styled-content style=\"fixed-case\">TCC<\/jats:styled-content>at codon 11 (S), while B*14:13 arose from B*14:02:01:01 which has GCC at codon 11 (A). Additionally, the two likely B*14:53\u2010bearing and B*14:13\u2010bearing haplotypes are typical of B*14:01:01\u2010bearing and B*14:02:01:01\u2010bearing haplotypes, respectively. Serological testing, using 49 antisera with<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B64, or B64, B65 reactivity, showed that the B*14:53 specificity did not react as a B64 (B*14:01) specificity and may appear as a short\/weak<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B14. This implies that residues additional to S at position 11 are involved in<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010B64 serological identity; for example, the motif 11S 97W 116F is possessed by B*14:01 and many other B*14 products (and B*39:79 plus some<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010C products) but not B65 (B*14:02) or the B*14:53 specificity. B*14:53 was found in a random<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>sequence\u2010based typed population of 32\u00a0530 normal subjects indicating a low precision allele frequency of 0.000015 in subjects resident in Wales.<\/jats:p>","DOI":"10.1111\/iji.12278","type":"journal-article","created":{"date-parts":[[2016,6,17]],"date-time":"2016-06-17T04:35:11Z","timestamp":1466138111000},"page":"236-239","source":"Crossref","is-referenced-by-count":7,"title":["A novel<scp>HLA<\/scp>\u2010B*14 allele \u2013 B*14:53 \u2013 genetics and serology"],"prefix":"10.1111","volume":"43","author":[{"given":"J.","family":"Street","sequence":"first","affiliation":[{"name":"Welsh Transplantation and Immunogenetics Laboratory Welsh Blood Service Pontyclun Wales UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Davies","sequence":"additional","affiliation":[{"name":"Welsh Transplantation and Immunogenetics Laboratory Welsh Blood Service Pontyclun Wales UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Darke","sequence":"additional","affiliation":[{"name":"Welsh Transplantation and Immunogenetics Laboratory Welsh Blood Service Pontyclun Wales UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1980.tb00200.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1983.tb00165.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1984.tb00011.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/oso\/9780199633647.003.0003","volume-title":"Histocompatibility Testing: A Practical Approach","author":"Darke C.","year":"1993"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1977.tb00768.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1993.tb01989.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.08.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1166"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12304"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(97)01093-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.038497"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2010.01466.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1161"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12278","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T18:08:13Z","timestamp":1718647693000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,16]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/iji.12278"],"URL":"https:\/\/doi.org\/10.1111\/iji.12278","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,16]]}}}