{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:34:10Z","timestamp":1781274850837,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["04\u20102010\u20100370"],"award-info":[{"award-number":["04\u20102010\u20100370"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2016,10]]},"abstract":"Summary<\/jats:title>The human leucocyte antigen (HLA<\/jats:styled-content>) system is the most polymorphic genetic system in humans, and HLA<\/jats:styled-content> matching is crucial in organ transplantation, especially in hematopoietic stem cell transplantation. We investigated HLA<\/jats:styled-content>\u2010A, HLA<\/jats:styled-content>\u2010B and HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1 allele and haplotype frequencies at allelic level in 10\u00a0918 Koreans from bone marrow donor registry in Korea. Intermediate resolution HLA<\/jats:styled-content> typing was performed using Luminex technology (Wakunaga, Japan), and additional allelic level typing was performed using PCR<\/jats:styled-content>\u2013single\u2010strand conformation polymorphism method and\/or sequence\u2010based typing (Abbott Molecular, USA<\/jats:styled-content>). Allele and haplotype frequencies were calculated by direct counting and maximum likelihood methods, respectively. A total of 39 HLA<\/jats:styled-content>\u2010A, 66 HLA<\/jats:styled-content>\u2010B and 47 HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1 alleles were identified. High\u2010frequency alleles found at a frequency of \u22655% were 6 HLA<\/jats:styled-content>\u2010A (A*02:01<\/jats:italic>, *02:06<\/jats:italic>, *11:01<\/jats:italic>, *24:02<\/jats:italic>, *31:01<\/jats:italic> and *33:03<\/jats:italic>), 6 HLA<\/jats:styled-content>\u2010B (B*15:01<\/jats:italic>, *35:01<\/jats:italic>, *44:03<\/jats:italic>, *51:01<\/jats:italic>, 54:01<\/jats:italic> and *58:01<\/jats:italic>) and 8 HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1 (DRB<\/jats:styled-content>1*01:01<\/jats:italic>, *04:05<\/jats:italic>, *04:06<\/jats:italic>, *07:01<\/jats:italic>, *08:03<\/jats:italic>, *09:01<\/jats:italic>, *13:02<\/jats:italic> and *15:01<\/jats:italic>) alleles. At each locus, A*02, B*15 and DRB<\/jats:styled-content>1*14 generic groups were most\u00a0diverse at allelic level, consisting of 9, 12 and 11 different alleles, respectively. A total of 366, 197 and\u00a021 different HLA<\/jats:styled-content>\u2010A\u2010B\u2010DRB<\/jats:styled-content>1 haplotypes were estimated with frequencies of \u22650.05%, \u22650.1% and \u22650.5%, respectively. The five most common haplotypes with frequencies of \u22652.0% were A*33:03\u2010B*44:03\u2010DRB<\/jats:styled-content>1*13:02<\/jats:italic> (4.97%), A*33:03\u2010B*58:01\u2010DRB<\/jats:styled-content>1*13:02<\/jats:italic>, A*33:03\u2010B*44:03\u2010DRB<\/jats:styled-content>1*07:01<\/jats:italic>, A*24:02\u2010B*07:02\u2010DRB<\/jats:styled-content>1*01:01<\/jats:italic> and A*24:02\u2010B*52:01\u2010DRB<\/jats:styled-content>1*15:02<\/jats:italic>. Among 34 serologic HLA<\/jats:styled-content>\u2010A\u2010B\u2010DR<\/jats:styled-content> haplotypes with frequencies of \u22650.5%, 17 haplotypes revealed allele\u2010level diversity and majority of the allelic variation was arising from A2, A26, B61, B62, DR<\/jats:styled-content>4 and DR<\/jats:styled-content>14 specificities. Haplotype diversity obtained in this study is the most comprehensive data thus far reported in Koreans, and the information will be useful for unrelated stem cell transplantation as well as for disease association studies.<\/jats:p>","DOI":"10.1111\/iji.12288","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T09:33:44Z","timestamp":1470908024000},"page":"287-296","source":"Crossref","is-referenced-by-count":19,"title":["HLA<\/scp>\u2010A, HLA<\/scp>\u2010B and HLA<\/scp>\u2010DRB<\/scp>1 allele and haplotype frequencies of 10\u00a0918 Koreans from bone marrow donor registry in Korea"],"prefix":"10.1111","volume":"43","author":[{"given":"H.","family":"Park","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Seegene Medical Foundation Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.\u2010j.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Y.","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. H.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Seoul National University College of Medicine Seoul Korea"},{"name":"Korea Organ Donation Agency Laboratory Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.1994.tb00170.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-8859(96)00016-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(01)00298-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3343\/kjlm.2010.30.6.685"},{"key":"e_1_2_7_6_1","first-page":"47","article-title":"Arlequin (version 3.0): an integrated software package for population genetics data analysis","volume":"1","author":"Excoffier L.","year":"2007","journal-title":"Evolutionary Bioinformatics Online"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2307\/2532296"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12254"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2009.00866.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12067"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12536"},{"key":"e_1_2_7_12_1","first-page":"627","volume-title":"HLA 1991","author":"Imanishi T.","year":"1992"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2015.35.4.429"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2005.00386.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12093"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.12067"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2015.11.013"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2006.00529.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0139485"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12288","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12288","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T21:57:33Z","timestamp":1695765453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,11]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1111\/iji.12288"],"URL":"https:\/\/doi.org\/10.1111\/iji.12288","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,11]]}}}