{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T12:16:13Z","timestamp":1754482573082},"reference-count":50,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T00:00:00Z","timestamp":1476748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["92\u201003\u201030\u201024902"],"award-info":[{"award-number":["92\u201003\u201030\u201024902"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Juvenile idiopathic arthritis (<jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>) is a heterogeneous autoimmune disorder of unknown origin. As proinflammatory cytokines are known to contribute towards the pathogenesis of <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>, this case\u2013control study was performed to examine the associations of certain single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) of tumour necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010<jats:italic>\u03b1<\/jats:italic>) gene. Fifty\u2010three patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> participated in this study as patients group and compared with 137 healthy unrelated controls. Genotyping was performed for <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1<\/jats:italic> gene at positions \u2010308 and \u2010238, using polymerase chain reaction with sequence\u2010specific primers method. Results of the analysed data revealed a significant positive association for <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1<\/jats:italic> gene at positions \u2010308 and \u2010238 for A allele in patients group compared with controls (<jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.01). At the genotypic level, the frequency of <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1<\/jats:italic> gene at positions \u2010308 and \u2010238 for <jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> genotype was discovered to be higher in the patients with <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content> compared to the healthy controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01), while <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> genotype at the same positions was observed to be less frequent in the case group than the controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). At the haplotypic level, a significant positive association for <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 <\/jats:italic><jats:styled-content style=\"fixed-case\">GG<\/jats:styled-content> haplotype (positions \u2010308, \u2010238) together with a notable negative association for <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 <\/jats:italic><jats:styled-content style=\"fixed-case\">AG<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GA<\/jats:styled-content> haplotypes at the same positions were detected in the patients group in comparison with the healthy individuals (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Cytokine gene polymorphisms might affect the development of <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>. Particular <jats:italic><jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1<\/jats:italic> gene variants could render individuals more susceptible to <jats:styled-content style=\"fixed-case\">JIA<\/jats:styled-content>..<\/jats:p>","DOI":"10.1111\/iji.12291","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T09:16:52Z","timestamp":1476782212000},"page":"391-396","source":"Crossref","is-referenced-by-count":7,"title":["Association of tumour necrosis factor\u2010alpha G\/A \u2010238 and G\/A \u2010308 single nucleotide polymorphisms with juvenile idiopathic arthritis"],"prefix":"10.1111","volume":"43","author":[{"given":"M.","family":"Maddah","sequence":"first","affiliation":[{"name":"Pediatrics Center of Excellence Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Harsini","sequence":"additional","affiliation":[{"name":"Research Center for Immunodeficiencies Children's Medical Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Network of Immunity in Infection Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Ziaee","sequence":"additional","affiliation":[{"name":"Pediatrics Center of Excellence Children's Medical Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Pediatric Rheumatology Research Group Rheumatology Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. H.","family":"Moradinejad","sequence":"additional","affiliation":[{"name":"Pediatrics Center of Excellence Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Research Center for Immunodeficiencies Children's Medical Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zoghi","sequence":"additional","affiliation":[{"name":"Network of Immunity in Infection Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN) Tehran Iran"},{"name":"Department of Immunology School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sadr","sequence":"additional","affiliation":[{"name":"Molecular Immunology Research Center School of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Aghighi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Imam Khomeini Hospital Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Research Center for Immunodeficiencies Children's Medical Center Tehran University of Medical Sciences Tehran Iran"},{"name":"Network of Immunity in Infection Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN) Tehran Iran"},{"name":"Department of Immunology School of Medicine Tehran University of Medical Sciences Tehran Iran"},{"name":"Molecular Immunology Research Center School of Medicine Tehran University of Medical Sciences Tehran 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