{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:17:39Z","timestamp":1782476259537,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,5]],"date-time":"2017-02-05T00:00:00Z","timestamp":1486252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["26293128"],"award-info":[{"award-number":["26293128"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Summary<\/jats:title>To clarify the association between the genetic producibility of IL<\/jats:styled-content>\u201015, a pro\u2010inflammatory cytokine, and the pathogenesis of autoimmune thyroid diseases (AITD<\/jats:styled-content>s), we genotyped +96522 A>T and +82889 A>G polymorphisms in the IL<\/jats:styled-content>15<\/jats:italic> gene using 127 patients with Hashimoto's disease (HD<\/jats:styled-content>), including 55 patients with severe HD<\/jats:styled-content> and 48 patients with mild HD<\/jats:styled-content>; 130 patients with Graves\u2019 disease (GD<\/jats:styled-content>), including 52 patients with intractable GD<\/jats:styled-content> and 44 patients with GD<\/jats:styled-content> in remission; and 79 healthy volunteers. Both the IL<\/jats:styled-content>15<\/jats:italic> +96522 A allele and AA<\/jats:styled-content> genotype were more frequent in patients with severe HD<\/jats:styled-content> than in those with mild HD<\/jats:styled-content>. The serum levels of IL<\/jats:styled-content>\u201015 were higher in individuals with the IL<\/jats:styled-content>15<\/jats:italic> +96522 AA<\/jats:styled-content> genotype than in those with the T allele, and they were also higher in patients with severe HD<\/jats:styled-content> than in those with mild HD<\/jats:styled-content>. On the other hand, the mRNA<\/jats:styled-content> levels of IL<\/jats:styled-content>\u201015 were not significantly different among individuals with each genotype of both SNP<\/jats:styled-content>s. After incubation with recombinant human IL<\/jats:styled-content>\u201015, the proportions of Th17 cells in CD<\/jats:styled-content>4+<\/jats:sup> cells were increased, and those of Treg cells in CD<\/jats:styled-content>4+<\/jats:sup> cells were maintained. Our study indicates that the IL<\/jats:styled-content>15<\/jats:italic> +96522A\/C polymorphism correlates with the severity of HD<\/jats:styled-content>, most likely by increasing Th17 cells.<\/jats:p>","DOI":"10.1111\/iji.12305","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T04:02:47Z","timestamp":1486353767000},"page":"41-50","source":"Crossref","is-referenced-by-count":4,"title":["The IL<\/scp>15<\/i> +96522 A>T functional polymorphism is related to the differentiation of Th17 cells and the severity of Hashimoto's disease"],"prefix":"10.1111","volume":"44","author":[{"given":"Y.","family":"Arakawa","sequence":"first","affiliation":[{"name":"Department of Biomedical Informatics Division of Health Sciences Osaka University Graduate School of Medicine Suita Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics 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