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Fungal sensitization is common, and many patients with severe asthma with fungal sensitization (<jats:styled-content style=\"fixed-case\">SAFS<\/jats:styled-content>), used to denote this subgroup of asthma, respond to antifungal therapy. We have investigated 325 haplotype\u2010tagging <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s in 22 candidate genes previously associated with aspergillosis in patients with <jats:styled-content style=\"fixed-case\">SAFS<\/jats:styled-content>, with comparisons in atopic asthmatics and healthy control patients, of whom 47 <jats:styled-content style=\"fixed-case\">SAFS<\/jats:styled-content>, 279 healthy and 152 atopic asthmatic subjects were genotyped successfully. Significant associations with <jats:styled-content style=\"fixed-case\">SAFS<\/jats:styled-content> compared with atopic asthma included Toll\u2010like receptor 3 (<jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>3) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.009), <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>9 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.025), C\u2010type lectin domain family seven member A (dectin\u20101) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.043), interleukin\u201010 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0010), mannose\u2010binding lectin (<jats:styled-content style=\"fixed-case\">MBL<\/jats:styled-content>2) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.007), <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\u2010chemokine ligand 2 (<jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>2) (2 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.025 and .041), <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>17 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002), plasminogen (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.049) and adenosine A2a receptor (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.024). These associations differ from those found in <jats:styled-content style=\"fixed-case\">ABPA<\/jats:styled-content> in asthma, indicative of contrasting disease processes. Additional and broader genetic association studies in <jats:styled-content style=\"fixed-case\">SAFS<\/jats:styled-content>, combined with experimental work, are likely to contribute to our understanding of different phenotypes of problematic asthma.<\/jats:p>","DOI":"10.1111\/iji.12312","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T07:34:44Z","timestamp":1490945684000},"page":"93-106","source":"Crossref","is-referenced-by-count":37,"title":["Genetic susceptibility to severe asthma with fungal sensitization"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0962-0268","authenticated-orcid":false,"given":"N. L.","family":"Overton","sequence":"first","affiliation":[{"name":"Division of Infection Immunity and Respiratory Medicine School of Biological Sciences Faculty of Biology Medicine and Health Manchester Academic Health Science Centre University Hospital of South Manchester NHS Foundation Trust The University of Manchester  Manchester UK"},{"name":"Manchester Fungal Infection Group (MFIG) The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Division of Infection Immunity and Respiratory Medicine School of Biological Sciences Faculty of Biology Medicine and Health Manchester Academic Health Science Centre University Hospital of South Manchester NHS Foundation Trust The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bowyer","sequence":"additional","affiliation":[{"name":"Division of Infection Immunity and Respiratory Medicine School of Biological Sciences Faculty of Biology Medicine and Health Manchester Academic Health Science Centre University Hospital of South Manchester NHS Foundation Trust The University of Manchester  Manchester UK"},{"name":"Manchester Fungal Infection Group (MFIG) The University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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