{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:03:57Z","timestamp":1790420637171,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,18]],"date-time":"2017-06-18T00:00:00Z","timestamp":1497744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["181798"],"award-info":[{"award-number":["181798"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Summary<\/jats:title>Turner syndrome (TS<\/jats:styled-content>) is one of the most common sexual chromosome abnormalities and is clearly associated with an increased risk of autoimmune diseases, particularly thyroid disease and coeliac disease (CD<\/jats:styled-content>). Single\u2010nucleotide polymorphism analyses have been shown to provide correlative evidence that specific genes are associated with autoimmune disease. Our aim was to study the functional polymorphic variants of PTPN<\/jats:styled-content>22 and ZFAT<\/jats:styled-content> in relation to thyroid disease and those of MYO<\/jats:styled-content>9B in relation to CD<\/jats:styled-content>. A cross\u2010sectional comparative analysis was performed on Mexican mestizo patients with TS<\/jats:styled-content> and age\u2010matched healthy females. Our data showed that PTPN<\/jats:styled-content>22 C1858T (considered a risk variant) is not associated with TS<\/jats:styled-content> (X2<\/jats:sup>\u00a0=\u00a03.50, p<\/jats:italic>\u00a0=\u00a0.61, and OR<\/jats:styled-content>\u00a0=\u00a00.33 [95% CI<\/jats:styled-content>\u00a0=\u00a00.10\u20131.10]). Also, ZFAT<\/jats:styled-content> was not associated with TS<\/jats:styled-content> (X2<\/jats:sup>\u00a0=\u00a01.2, p<\/jats:italic>\u00a0=\u00a0.28, and OR<\/jats:styled-content>\u00a0=\u00a01.22 [95% CI<\/jats:styled-content>\u00a0=\u00a00.84\u20131.79]). However, for the first time, rs2305767 MYO<\/jats:styled-content>9B was revealed to have a strong association with TS<\/jats:styled-content> (X2\u00a0<\/jats:sup>=\u00a058.6, p<\/jats:italic>\u00a0=\u00a0.0001, and OR<\/jats:styled-content>\u00a0=\u00a010.44 [95% C\u00a0=\u00a05.51\u201319.80]), supporting a high level of predisposition to CD<\/jats:styled-content> among TS<\/jats:styled-content> patients. This report addresses additional data regarding the polymorphic variants associated with autoimmune disease, one of the most common complications in TS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/iji.12323","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T04:02:37Z","timestamp":1497844957000},"page":"153-157","source":"Crossref","is-referenced-by-count":10,"title":["Analysis of PTPN<\/scp>22, ZFAT<\/scp> and MYO<\/scp>9B polymorphisms in Turner Syndrome and risk of autoimmune disease"],"prefix":"10.1111","volume":"44","author":[{"given":"E.","family":"Villanueva\u2010Ortega","sequence":"first","affiliation":[{"name":"Human Genetic Department Hospital General de M\u00e9xico Eduardo Liceaga Mexico City Mexico"},{"name":"Facultad de Medicina Universidad Nacional Autonoma de Mexico Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Ahedo","sequence":"additional","affiliation":[{"name":"Human Genetic Department Hospital General de M\u00e9xico Eduardo Liceaga Mexico City Mexico"},{"name":"Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A.","family":"Fonseca\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Human Genetic Department Hospital General de M\u00e9xico Eduardo Liceaga Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"P\u00e9rez\u2010Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Diagnosis NanoLab Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Garibay\u2010Nieto","sequence":"additional","affiliation":[{"name":"Human Genetic Department Hospital General de M\u00e9xico Eduardo Liceaga Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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