{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:37:29Z","timestamp":1789850249715,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/50250\u20106"],"award-info":[{"award-number":["2014\/50250\u20106"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Cytotoxic T\u2010lymphocyte\u2010associated antigen 4 (<jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104) molecule is expressed on <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010lymphocyte membrane and negatively influences the antigen\u2010presenting process. Reduced expression of <jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104 due to gene polymorphisms is associated with increased risk of autoimmune disorders, whose physiopathology is similar to that of post\u2010transfusion red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) alloimmunization. Our goal was to evaluate if polymorphisms of <jats:italic><jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104<\/jats:italic> gene that affect protein expression are associated with <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> alloimmunization. This was a case\u2013control study in which 134 sickle cell disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>) patients and 253 non\u2010<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> patients were included. All patients were genotyped for the polymorphisms 49A\/G and \u2010318C\/T of <jats:italic><jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104<\/jats:italic> gene. The genotype frequency of \u2010318C\/T differed significantly between alloimmunized and nonalloimmunized <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> patients, irrespective of clinical confounders (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.016). <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> patients heterozygous for \u2010318T allele presented higher risk of alloantibody development (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>: 5.4, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.15\u201325.6). In conclusion, the polymorphism \u2010318C\/T of <jats:italic><jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104<\/jats:italic> gene is associated with <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> alloimmunization among <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> patients. This highlights the role played by <jats:styled-content style=\"fixed-case\">CTLA<\/jats:styled-content>\u20104 on post\u2010transfusion alloantibody development.<\/jats:p>","DOI":"10.1111\/iji.12334","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T08:37:24Z","timestamp":1502959044000},"page":"219-224","source":"Crossref","is-referenced-by-count":20,"title":["\u2010318C\/T polymorphism of the <i><scp>CTLA<\/scp>\u20104<\/i> gene is an independent risk factor for <scp>RBC<\/scp> alloimmunization among sickle cell disease patients"],"prefix":"10.1111","volume":"44","author":[{"given":"V. B.","family":"Oliveira","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. R.","family":"Dezan","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. C. A.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. F.","family":"Menosi Gualandro","sequence":"additional","affiliation":[{"name":"Discipline of Hematology University of S\u00e3o Paulo School of Medicine  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Krieger","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Molecular Cardiology Heart Institute (InCor) University of S\u00e3o Paulo School of Medicine  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Molecular Cardiology Heart Institute (InCor) University of S\u00e3o Paulo School of Medicine  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"Marsiglia","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics and Molecular Cardiology Heart Institute (InCor) University of S\u00e3o Paulo School of Medicine  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Levi","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Rocha","sequence":"additional","affiliation":[{"name":"Discipline of Hematology University of S\u00e3o Paulo School of Medicine  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mendrone\u2010Junior","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue Hemocentro de S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. C.","family":"Sabino","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0453-7863","authenticated-orcid":false,"given":"C. 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