{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:39:36Z","timestamp":1780731576976,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,11,3]],"date-time":"2017-11-03T00:00:00Z","timestamp":1509667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010629","name":"Fulbright Association","doi-asserted-by":"publisher","award":["CAPES\u2010Fulbright Fellowship"],"award-info":[{"award-number":["CAPES\u2010Fulbright Fellowship"]}],"id":[{"id":"10.13039\/100010629","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006675","name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006675","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["PHD fellowship"],"award-info":[{"award-number":["PHD fellowship"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The effect of <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G<\/jats:italic> 14\u00a0bp Ins\/Del polymorphism (rs371194629) on the risk of preeclampsia has been assessed in several populations, yet the results are still conflicting. Lack of power due to small sample sizes is a common cause of inconsistencies in genetic association studies. We aimed to test whether the maternal polymorphism is associated with preeclampsia, eclampsia or <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome (acronym for Hemolysis, Elevation of Liver enzymes, Low Platelets). To achieve a statistical power greater than 0.90, a total of 741 women (332 controls, 246 preeclampsia, 57 eclampsia and 106 <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content>) were genotyped for the 14\u2010bp Ins\/Del polymorphism. The genetic association with disease status was assessed by Fisher's exact test and odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) estimates using logistic regression model adjusted for maternal age and parity status. Allele and genotype distributions were the same between control and case groups (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a0.05). The polymorphism was not associated with the risk of developing preeclampsia [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.93 (0.72\u20131.19); <jats:italic>p<\/jats:italic>\u00a0=\u00a0.541], or eclampsia [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.90 (0.60\u20131.38); <jats:italic>p<\/jats:italic>\u00a0=\u00a0.628] nor <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.92 (0.66\u20131.28); <jats:italic>p<\/jats:italic>\u00a0=\u00a0.628]. This well\u2010powered study clearly demonstrates that the maternal <jats:italic><jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010G<\/jats:italic> 14\u2010bp Ins\/Del polymorphism is not associated with preeclampsia risk. However, as the offspring genotypes were not evaluated here, we could not rule out the effect of the foetal genotype on the preeclampsia pathogenesis.<\/jats:p>","DOI":"10.1111\/iji.12344","type":"journal-article","created":{"date-parts":[[2017,11,4]],"date-time":"2017-11-04T03:52:48Z","timestamp":1509767568000},"page":"350-355","source":"Crossref","is-referenced-by-count":8,"title":["The maternal 14\u00a0bp Ins\/Del polymorphism in <i><scp>HLA<\/scp>\u2010G<\/i> is not associated with preeclampsia risk"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9268-4881","authenticated-orcid":false,"given":"L. C.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Department of Biochemistry Federal University of Rio Grande do Norte  Natal Brazil"},{"name":"Institute of Tropical Medicine Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. P. B.","family":"Lopes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. B.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. E. M.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine Federal University of Rio Grande do Norte  Natal Brazil"},{"name":"Department of Biophysics and Pharmacology Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M. B.","family":"Jeronimo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Federal University of Rio Grande do Norte  Natal Brazil"},{"name":"Institute of Tropical Medicine Federal University of Rio Grande do Norte  Natal Brazil"},{"name":"Institute of Science and Technology of Tropical Diseases  Natal Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2007.04.007"},{"key":"e_1_2_6_3_1","first-page":"1122","article-title":"Hypertension in pregnancy. 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