{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T16:10:12Z","timestamp":1778947812430,"version":"3.51.4"},"reference-count":54,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T00:00:00Z","timestamp":1518393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006312","name":"South African Agency for Science and Technology Advancement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2018,4]]},"abstract":"Summary<\/jats:title>Interleukin (IL<\/jats:styled-content>\u2010)17A, plays a role in pathogenic defence, but is implicated in chronic inflammatory diseases, and has recently been associated with variable pregnancy outcomes. We investigated the role of maternal IL<\/jats:styled-content>\u201017\u2010[G197A]\u2010specific effects of third\u2010trimester IL<\/jats:styled-content>\u201017 mRNA<\/jats:styled-content> expression, NO<\/jats:styled-content>x<\/jats:sub> exposure levels and other variables on gestational age, in the Mother and Child in the Environment (MACE<\/jats:styled-content>) birth cohort in South Africa. A total of 327 participants were genotyped for IL<\/jats:styled-content>\u201017\u2010[G197A] by polymerase chain reaction restriction\u2010fragment length polymorphism (PCR<\/jats:styled-content>\u2010RFLP<\/jats:styled-content>). Quantitative real\u2010time PCR<\/jats:styled-content> was used to quantitate IL<\/jats:styled-content>\u201017\u2010mRNA<\/jats:styled-content> expression in whole blood. Multivariate linear regression analysis, stratified by IL<\/jats:styled-content>\u201017\u2010[G197A] genotype, was used to test for effects of NO<\/jats:styled-content>x<\/jats:sub>, IL<\/jats:styled-content>17A\/GAPDH<\/jats:styled-content>, haemoglobin, body mass index, HIV<\/jats:styled-content>\u20101 positivity, maternal education and income level on gestational age. Lower expression was associated with the IL<\/jats:styled-content>\u201017\u2010GG<\/jats:styled-content> versus GA<\/jats:styled-content> in the cohort and HIV<\/jats:styled-content>\u20101\u2010negative group (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.0007, p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.0058), while no difference was observed in the HIV<\/jats:styled-content>\u20101 positives. Elevated IL<\/jats:styled-content>\u201017A expression was observed in the high NO<\/jats:styled-content>x<\/jats:sub> exposure groups, within IL<\/jats:styled-content>\u201017[G197G] (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.0004). IL<\/jats:styled-content>\u201017[G197G] was associated with PTB<\/jats:styled-content> (p\u00a0<\/jats:italic><\u00a0<\/jats:italic>.0001), and the PTB<\/jats:styled-content> group had lower IL<\/jats:styled-content>\u201017A expression compared to the full\u2010term group (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.0002). IL<\/jats:styled-content>\u201017 expression was associated with an increase in gestational age (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.038), and NO<\/jats:styled-content>x<\/jats:sub> was associated with a decrease in gestational age in the IL<\/jats:styled-content>\u201017[G197G] model (p\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.046).<\/jats:p>","DOI":"10.1111\/iji.12358","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T11:50:30Z","timestamp":1518436230000},"page":"54-62","source":"Crossref","is-referenced-by-count":3,"title":["IL<\/scp>\u201017A[G197G]\u2014Association between NO<\/scp>x<\/sub> and gestational age in a South African birth cohort"],"prefix":"10.1111","volume":"45","author":[{"given":"P.","family":"Nansook","sequence":"first","affiliation":[{"name":"Discipline of Medical Biochemistry School of Laboratory Medicine and Medical Sciences University of KwaZulu\u2010Natal Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. N.","family":"Naidoo","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health School of Nursing and Public Health Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Muttoo","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health School of Nursing and Public Health Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Asharam","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health School of Nursing and Public Health Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ramkaran","sequence":"additional","affiliation":[{"name":"Discipline of Medical Biochemistry School of Laboratory Medicine and Medical Sciences University of KwaZulu\u2010Natal Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Phulukdaree","sequence":"additional","affiliation":[{"name":"Discipline of Medical Biochemistry School of Laboratory Medicine and Medical Sciences University of KwaZulu\u2010Natal Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4649-4133","authenticated-orcid":false,"given":"A. A.","family":"Chuturgoon","sequence":"additional","affiliation":[{"name":"Discipline of Medical Biochemistry School of Laboratory Medicine and Medical Sciences University of KwaZulu\u2010Natal Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2010.02.018"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2011.09.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01838-13"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.06.048"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10952"},{"issue":"6","key":"e_1_2_8_7_1","first-page":"880","article-title":"Prenatal exposure to outdoor air pollution and preterm birth: A Meta\u2010analysis","volume":"37","author":"Chen Y.","year":"2016","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020333"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2800"},{"issue":"10","key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"e0164741","DOI":"10.1371\/journal.pone.0164741","article-title":"Effect of environmental factors on low weight in non\u2010premature births: a time series analysis","volume":"11","author":"D\u00edaz J.","year":"2016","journal-title":"PLoS ONE"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2295"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652015000200003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026229"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1306837"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2014.54"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.2010.01017.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2006.00759.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2009.09.005"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1465-9921-6-44","article-title":"Interleukin\u201017A mRNA and protein expression within cells from the human bronchoalveolar space after exposure to organic dust","volume":"6","author":"Ivanov S.","year":"2005","journal-title":"Respiratory Research"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2016.11.100"},{"issue":"3","key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1504\/IJENVH.2008.020929","article-title":"The relationship between asthma and ambient air pollutants among primary school students in Durban, South Africa","volume":"2","author":"Kistnasamy E. J.","year":"2008","journal-title":"International Journal of Environment and Health"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-010-0633-4"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8733"},{"key":"e_1_2_8_25_1","first-page":"2979846","article-title":"Interleukin\u201017A gene variability in patients with type 1 diabetes mellitus and chronic periodontitis: Its correlation with IL\u201017 levels and the occurrence of periodontopathic bacteria","volume":"2016","author":"Linhartova P. B.","year":"2016","journal-title":"Mediators of Inflammation"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445404"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.6251"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2010.09.009"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00893.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/21650020.2014.896223"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.117929"},{"key":"e_1_2_8_32_1","unstructured":"Naidoo R. N. Gqaleni N. Batterman S. &Robins T.(2007).South Durban Health Study Final Project Report Multipoint Plan: Project 4 Health Study and Health Risk Assessment. Retrieved fromhttp:\/\/doeh.ukzn.ac.za\/Libraries\/Documents\/SDHS_FINAL_Report_revision_February_2007.sflb.ashx"},{"issue":"2","key":"e_1_2_8_33_1","first-page":"60","article-title":"Progesterone supplementation and the prevention of preterm birth","volume":"4","author":"Norwitz E. R.","year":"2011","journal-title":"Reviews in Obstetrics and Gynecology"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph9010272"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.004"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2009.00693.x"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-9-23"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.05.011"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200009000-00004"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.046417"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2014-205387"},{"issue":"5","key":"e_1_2_8_42_1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1289\/ehp.7646","article-title":"A time series analysis of air pollution and preterm birth in Pennsylvania, 1997\u20132001","volume":"113","author":"Sagiv S. K.","year":"2005","journal-title":"Environmental Health Perspectives"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00852.x"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901461"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2016.01.004"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.2741\/spencer"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2011.00987.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082545"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2009.12.003"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(15)00207-6"},{"issue":"3","key":"e_1_2_8_51_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/00016347709162009","article-title":"WHO: Recommended definitions, terminology and format for statistical tables related to the perinatal period and use of a new certificate for cause of perinatal deaths","volume":"56","author":"WHO","year":"1977","journal-title":"Acta Obstetricia et Gynecologica Scandinavica"},{"key":"e_1_2_8_52_1","unstructured":"World Health Organization (WHO)(2016).Congenital Anomalies Fact sheet. Retrieved fromhttp:\/\/www.who.int\/mediacentre\/factsheets\/fs370\/en\/"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800334"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.12.5483"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401810"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12358","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12358","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T23:41:28Z","timestamp":1695685288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,12]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/iji.12358"],"URL":"https:\/\/doi.org\/10.1111\/iji.12358","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,12]]}}}