{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:33:49Z","timestamp":1778855629394,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T00:00:00Z","timestamp":1521936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Departmental Resources"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We reported previously on the widespread occurrence of anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> alloantibodies of the IgA isotype (anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> IgA) in the sera of solid\u2010organ re\u2010transplantation (re\u2010tx) candidates (Arnold et\u00a0al., <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#iji12363-bib-0001\"\/>). Specifically focussing on kidney re\u2010tx patients, we now extended our earlier findings by examining the impact of the presence and donor specificity of anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> IgA on graft survival. We observed frequent concurrence of anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> IgA and anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> IgG in 27% of our multicenter collective of 694 kidney re\u2010tx patients. This subgroup displayed significantly reduced graft survival as evidenced by the median time to first dialysis after transplantation (<jats:styled-content style=\"fixed-case\">TTD<\/jats:styled-content> 77\u00a0months) compared to patients carrying either anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> IgG or IgA (<jats:styled-content style=\"fixed-case\">TTD<\/jats:styled-content> 102 and 94\u00a0months, respectively). In addition, donor specificity of anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> IgA had a significant negative impact on graft survival (<jats:styled-content style=\"fixed-case\">TTD<\/jats:styled-content> 74\u00a0months) in our study. Taken together, our data strongly indicate that presence of anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> IgA, in particular in conjunction with anti\u2010<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010IgG, in sera of kidney re\u2010tx patients is associated with negative transplantation outcome.<\/jats:p>","DOI":"10.1111\/iji.12363","type":"journal-article","created":{"date-parts":[[2018,3,25]],"date-time":"2018-03-25T13:36:04Z","timestamp":1521984964000},"page":"95-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Anti\u2010<scp>HLA<\/scp> alloantibodies of the IgA isotype in re\u2010transplant candidates part <scp>II<\/scp>: Correlation with graft survival"],"prefix":"10.1111","volume":"45","author":[{"given":"M.\u2010L.","family":"Arnold","sequence":"first","affiliation":[{"name":"Department of Internal Medicine 3 \u2010 Rheumatology and Immunology Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg (FAU) Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4675-7896","authenticated-orcid":false,"given":"C.","family":"Bach","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 5 \u2010 Hematology and Oncology Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg (FAU) Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. M.","family":"Heinemann","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine University Hospital Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Horn","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine University Hospital Essen  Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ziemann","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine University Hospital of Schleswig\u2010Holstein  L\u00fcbeck\u2010 Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Lachmann","sequence":"additional","affiliation":[{"name":"HLA Laboratory Center for Tumor Medicine Charit\u00e9  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"M\u00fchlbacher","sequence":"additional","affiliation":[{"name":"Central Institute for Blood Transfusion and Immunology General Hospital and University Clinics  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dick","sequence":"additional","affiliation":[{"name":"Laboratory for Immunogenetics University Hospital Grosshadern Ludwig\u2010Maximilians\u2010University  Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ender","sequence":"additional","affiliation":[{"name":"Central Institute for Transfusion Medicine and Blood Donation Katharinenhospital Stuttgart  Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Thammanichanond","sequence":"additional","affiliation":[{"name":"Histocompatibility and Immunogenetics Laboratory Department of Pathology Mahidol University Bangkok  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Schaub","sequence":"additional","affiliation":[{"name":"HLA\u2010Diagnostics and Immunogenetics Department of Laboratory Medicine, Transplantation Immunology &amp; Nephrology Department of Biomedicine University Hospital Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"H\u00f6nger","sequence":"additional","affiliation":[{"name":"Transplantation Immunology and Nephrology Department of Biomedicine University Basel  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. F.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department for Blood Group Serology and Transfusion Medicine Medical University Vienna  Vienna Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Mytilineos","sequence":"additional","affiliation":[{"name":"Institute of Clinical Transfusion Medicine and Immunogenetics University Hospital of Ulm  Ulm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hallensleben","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine Hannover Medical School  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. E.","family":"Hitzler","sequence":"additional","affiliation":[{"name":"Transfusion Center University Medical Center Johannes Gutenberg\u2010University Mainz  Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Seidl","sequence":"additional","affiliation":[{"name":"German Red Cross Blood Donor Service Institute for Transfusion Medicine and Immunohaematology  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. M.","family":"Spriewald","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 5 \u2010 Hematology and Oncology Friedrich\u2010Alexander\u2010University Erlangen\u2010N\u00fcrnberg (FAU) Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12032"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2011.07.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2009.02799.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2012.01453.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181e065de"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2007.03545.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199607270-00009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199307000-00038"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200210270-00025"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014111120"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs472"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000269725.74189.b9"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.5.2861"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2011.03840.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2015.01.011"},{"issue":"5","key":"e_1_2_8_17_1","first-page":"2663","article-title":"Pretransplant IgA\u2010anti\u2010hinge and IgA\u2010anti\u2010Fab autoantibody activity is associated with good kidney graft survival","volume":"27","author":"Susal C.","year":"1995","journal-title":"Transplantation Proceedings"},{"issue":"1","key":"e_1_2_8_18_1","first-page":"1072","article-title":"Excellent kidney graft survival in patients with high pretransplant serum IgA concentrations and IgA\u2010anti\u2010Fab autoantibody activity","volume":"27","author":"Susal C.","year":"1995","journal-title":"Transplantation Proceedings"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199601270-00007"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12363","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:45:15Z","timestamp":1695480315000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12363"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,25]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1111\/iji.12363"],"URL":"https:\/\/doi.org\/10.1111\/iji.12363","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,25]]},"assertion":[{"value":"2017-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}