{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:15:51Z","timestamp":1747185351271,"version":"3.40.5"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pemphigus foliaceus (PF) is an autoimmune skin disease characterized by autoantibodies directed mainly against desmoglein\u20101. The purpose of this study was to determine whether differential susceptibility to endemic PF in Brazil (<jats:italic>fogo selvagem<\/jats:italic>) is associated with polymorphisms at the cytogenetic location 1p13.2. Four single nucleotide polymorphisms that together tag 28 SNPs on a segment of approximately 312,000\u00a0bp encompassing the protein\u2010coding genes <jats:italic>MAGI3, PHTF1, RSBN1, PTPN22, BCL2L15, AP4B1, DCLRE1B<\/jats:italic>, the pseudogenes <jats:italic>MTND5P20, RPS2P14 (AL133517.1)<\/jats:italic> and the long non\u2010coding RNA genes <jats:italic>AL137856.1,<\/jats:italic> and <jats:italic>AP4B1\u2010AS1<\/jats:italic> were used as markers for association analysis in a case\u2013control study. Allele, genotype and haplotype frequencies of <jats:italic>rs33996649<\/jats:italic>,<jats:italic> rs2476601<\/jats:italic>,<jats:italic> rs3789604<\/jats:italic> and <jats:italic>rs3195954<\/jats:italic> were compared between patient and control samples. No significant association was found. Lack of association with <jats:italic>rs2476601<\/jats:italic> of the <jats:italic>PTPN22<\/jats:italic> gene agrees with previous results for pemphigus vulgaris and the Tunisian form of endemic pemphigus foliaceus. The other three SNPs had never been analysed before in any form of pemphigus. We conclude that variants in structural and regulatory sites of region 1p13.2 are not susceptibility factors for <jats:italic>fogo selvagem<\/jats:italic>. We suggest careful investigation of this genomic region in diseases that had been previously associated with <jats:italic>PTPN22<\/jats:italic>, since there are several other genes relevant for immune\u2010mediated diseases located in 1p13.2.<\/jats:p>","DOI":"10.1111\/iji.12423","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T01:28:32Z","timestamp":1552958912000},"page":"139-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Region 1p13.2 including the <i>RSBN1, PTPN22, AP4B1<\/i> and long non\u2010coding RNA genes does not bear risk factors for endemic pemphigus foliaceus (<i>fogo selvagem<\/i>)"],"prefix":"10.1111","volume":"46","author":[{"given":"Sara Cristina","family":"Lobo\u2010Alves","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Molecular Humana Departamento de Gen\u00e9tica Universidade Federal do Paran\u00e1 Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liana Alves","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Molecular Humana Departamento de Gen\u00e9tica Universidade Federal do Paran\u00e1 Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-5276","authenticated-orcid":false,"given":"Maria Luiza","family":"Petzl\u2010Erler","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Gen\u00e9tica Molecular Humana Departamento de Gen\u00e9tica Universidade Federal do Paran\u00e1 Curitiba Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039991"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201445324"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0104"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/427244"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1323"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.041"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12919"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2011.04.032"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-015-1626-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2016.07.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21630"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2014.11.005"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120542109"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03617.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12028"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201701483R"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.5.1509"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010123"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel170"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.297"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12456932"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-017-1056-0"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2009.36"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-005-0795-y"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08170.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20771"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn363"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363939"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.08.006"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1989.tb01684.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2013.06.008"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200842"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10915-9"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198906013202206"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12192"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.30145"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01272.x"},{"issue":"1","key":"e_1_2_7_40_1","first-page":"pii: E3","article-title":"Besides pathology: Long non\u2010coding RNA in cell and tissue homeostasis","volume":"4","author":"Salviano\u2010Silva A.","year":"2018","journal-title":"Noncoding RNA"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2009.01.029"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08482.x"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807917"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.109"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.05.016"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20751"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1108"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel381"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.08.003"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2012.46"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iji.12423","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T16:33:08Z","timestamp":1694363588000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,18]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/iji.12423"],"URL":"https:\/\/doi.org\/10.1111\/iji.12423","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"type":"print","value":"1744-3121"},{"type":"electronic","value":"1744-313X"}],"subject":[],"published":{"date-parts":[[2019,3,18]]},"assertion":[{"value":"2018-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}