{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:32:40Z","timestamp":1766158360943,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non\u2010segmental vitiligo (NSV) is an autoimmune skin disease. Genetics plays a predominant part in disease pathogenesis. Nucleotide\u2010binding and oligomerization domain (NOD)\u2010like receptors and pyrin\u2010containing protein (NLRP) and Toll\u2010like receptors (TLR) are pattern recognition receptors in mediating innate immunity. They participate in presenting pathogens and mediating the immune responses. NLRP and TLRs are involved in mediating immune response in various dermatological diseases. Understanding the influence of genetic polymorphisms of NLRP and TLRs associated with immune homeostasis might help us to understand the complex etiopathogenesis of NSV. Thus, we aimed to study the association of NLRP\u20101 (rs2670660) and TLR\u20104 (rs4986790) and the synergistic effects on disease spectrum, disease activity of NSV in South Indian population. This research was designed as a case\u2013control genetic study with 264 patients and 264 controls. Genotyping of NLRP\u20101 (rs2670660) and TLR\u20104 (rs4986790) was performed by Taqman 5\u2019 allele discrimination assay and ARMS\u2010PCR. Plasma levels of proteins were measured by enzyme\u2010linked immunosorbent assay (ELISA). A statistically significant difference was observed with the frequency of homozygous GG genotype of NLRP\u20101 (rs2670660) (17.8% in cases vs. 5.3% in controls) (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001; OR\u20103.73; 95% CI\u20101.94\u20137.14). Allele G was significantly frequent in 38% of the cases than in controls with 30% (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.004; OR\u20101.46; 95% CI\u20101.13\u20131.89). Plasma NLRP\u20101 level was significantly higher in patients compared to controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Amongst cases, the plasma NLRP\u20101 levels did not show any difference with respect to their genotypes (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). In TLR\u20104 (rs4986790), no significant difference in the frequency of genotypes and allele between cases and controls (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.80) was observed; nevertheless, plasma TLR\u20104 was analogous between cases and controls (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05). Influence of genotype on plasma TLR\u20104 showed no significant difference in TLR\u20104 levels between GG and ancestral genotype AA, whilst heterozygous AG genotype showed a significant increase of TLR\u20104 compared to AA and GG (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.02) amongst NSV cases. The obtained results suggest that NLRP\u20101 (rs2670660), and not TLR\u20104 ((rs4986790), is associated with increased risk of NSV in South Indian population.<\/jats:p>","DOI":"10.1111\/iji.12429","type":"journal-article","created":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T04:53:45Z","timestamp":1562820825000},"page":"321-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of Nod\u2010like receptor protein\u20101 (rs2670660) and Toll\u2010like receptor\u20104 (rs4986790) with non\u2010segmental vitiligo: A case\u2013control study in South Indian population"],"prefix":"10.1111","volume":"46","author":[{"given":"Kalai Selvi","family":"Rajendiran","sequence":"first","affiliation":[{"name":"Department of Biochemistry Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7725-9676","authenticated-orcid":false,"given":"Medha","family":"Rajappa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laxmisha","family":"Chandrashekar","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devinder Mohan","family":"Thappa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Jawaharlal Institute of Postgraduate Medical Education and Research Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2013.768617"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-010-1064-1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/76048"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2003.12.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12467"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.01.032"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2016.07.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/437246"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep077"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-2328-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908547"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700953"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061592"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04514.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399401003362"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2011.05377.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.6A7101.2006"},{"key":"e_1_2_8_19_1","article-title":"The convergence theory for vitiligo: A reappraisal","author":"Kundu R. 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