{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:17:43Z","timestamp":1762543063558,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The increasing body of evidence for the relationship between the vascular endothelial growth factor (<jats:italic>VEGF<\/jats:italic>) polymorphism and autoimmune disorders combined with the enhanced expression of this angiogenic factor in vitiligo makes <jats:italic>VEGF<\/jats:italic> a very interesting candidate gene to be investigated in vitiligo. The aim of this study was to evaluate the possible associations between the +<jats:italic>405 G\/C<\/jats:italic> single nucleotide polymorphisms (SNP) of the <jats:italic>VEGF<\/jats:italic> gene (rs2010963) and vitiligo. The independent case\u2013control population sample of 152 patients with vitiligo and 152 matched controls was evaluated in this study. A questionnaire was completed for each vitiligo patient to document the demographic and clinical characteristics of the patients. All enrolled individuals had a venous blood sample collected. Genotype frequencies for +<jats:italic>405 G\/C VEGF<\/jats:italic> gene polymorphism were determined using polymerase chain reaction (PCR) amplification and restriction fragment length polymorphism (RFLP) analysis. There were no significant differences in genotype or allele distributions for this SNP between cases and controls. However, we observed a significant association between <jats:italic>GG<\/jats:italic> genotype and higher age at onset of vitiligo (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04). Moreover, patients stratification revealed a significant increase in the frequency of <jats:italic>GG<\/jats:italic> genotype compared to <jats:italic>CC + CG<\/jats:italic> genotypes in patients with the late onset (\u226520\u00a0years) vitiligo (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.05). Although these results are not conclusive, they could potentially lead to considering the angiogenic factors as a potential target for therapy in late\u2010onset vitiligo.<\/jats:p>","DOI":"10.1111\/iji.12432","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T09:53:08Z","timestamp":1559037188000},"page":"241-246","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Is the <i>+405 G\/C<\/i> single nucleotide polymorphism of the vascular endothelial growth factor (<i>VEGF<\/i>) gene associated with late\u2010onset vitiligo?"],"prefix":"10.1111","volume":"46","author":[{"given":"Mina","family":"Almasi\u2010Nasrabadi","sequence":"first","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa M.","family":"Amoli","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Molecular \u2010Cellular Sciences Institute, Metabolic Disorders Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7947-8642","authenticated-orcid":false,"given":"Reza M.","family":"Robati","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fateme","family":"Rajabi","sequence":"additional","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somayeh","family":"Parichehreh Dizaji","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Molecular \u2010Cellular Sciences Institute, Metabolic Disorders 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