{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:31:21Z","timestamp":1759159881712,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human papillomavirus (HPV) infection can lead to the development of productive epithelial lesions and cervical cancer. Most cervical HPV infections are solved by cell\u2010mediated immunity within 1\u20132\u00a0years, and it is known that chronic inflammation predisposes to lesions progression and tumour development. In this context, we highlight the CC chemokine receptor 5 (CCR5) which is involved in leucocytes chemotaxis to sites of inflammation, controlling the immune response. The CCR5 rs333 genotyping of 164 HPV infected women and 185 non\u2010infected women was performed using polymerase chain reaction (PCR). HPV infection was more frequent among women under 34\u00a0years old (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), single (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001), that received 1 minimum wage or less (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002), tobacco smokers (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007), who had the first sexual intercourse before 17\u00a0years old (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.038) and that had 4 or more sexual partners during lifetime (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.001). No significant difference regarding genotypes and alleles distribution according to HPV infection was observed. CCR5\/CCR5 genotype was observed in 94.1% of HPV non\u2010infected women and in 89% of infected ones, CCR5\/\u039432 in 5.9% of HPV infected and in 10.4% of non\u2010infected women, and \u039432\/\u039432 was observed in only one (0.6%) infected patient. CCR5 genotypes were also not associated with cervical lesions development among HPV infected women (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.167). Since CCR5 may control the antitumour immune response and cervical lesions and the studied rs333 polymorphism is not very frequent, other studies are necessary, in order to establish CCR5 role on HPV infection and squamous intraepithelial lesions development.<\/jats:p>","DOI":"10.1111\/iji.12444","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T07:49:50Z","timestamp":1560239390000},"page":"331-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>CCR5<\/i> genetic variants and epidemiological determinants for HPV infection and cervical premalignant lesions"],"prefix":"10.1111","volume":"46","author":[{"given":"Luis Fernando L.","family":"Mangieri","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Genetics and Immunology, Department of Pathological Science Londrina State University Londrina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle M.","family":"Sena","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics and Immunology, Department of Pathological Science Londrina State University Londrina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Cezar\u2010dos\u2010Santos","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics and Immunology, Department of Pathological Science Londrina State University Londrina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kleber P.","family":"Trugilo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics and Immunology, Department of Pathological Science Londrina State University Londrina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1dia C. 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