{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:58:29Z","timestamp":1783792709149,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Association Fran\u00e7aise des Polyarthritiques"},{"name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Rhumatologie"},{"name":"Association Rhumatisme et Travail"},{"name":"Association Polyarctique, Genopole\u00ae"},{"name":"Evry-Val d'Essonne University"},{"name":"Agence Th\u00e9matique de Recherche en Sciences de la Sant\u00e9 (ATRSS), Algeria"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Numerous single nucleotide polymorphisms (SNPs) were explored in the Algerian population to evaluate associated ankylosing spondylitis (AS) genetic risk factors, but no study has identified the impact of copy number variations (CNVs). The aim of the study was to determine whether CNVs of <jats:italic>CCL3L1<\/jats:italic>, <jats:italic>FCGR3A<\/jats:italic> and <jats:italic>FCGR3B<\/jats:italic> genes were also associated with the susceptibility of AS disease in Algerian population. The data set of the current study is composed of 81 patients with AS and 119 healthy controls. All samples were genotyped by digital droplet PCR (ddPCR). Chi\u2010square test and OR calculation were used to evaluate association between CNVs and AS and the risk associated with copy numbers (CN). In results, <jats:italic>FCGR3A<\/jats:italic> CN less than two copies (&lt;2) was significantly increased in spondylitis patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0001, OR\u00a0=\u00a07.74 [2.32\u201325.74]). Additionally, <jats:italic>FCGR3A CN<\/jats:italic>\u00a0&lt;\u00a02 copies association was present only in <jats:italic>HLA\u2010B27<\/jats:italic> (\u2010) patients. We have concluded that <jats:italic>FCGR3A<\/jats:italic> deletions have an independent effect on AS regarding HLA\u2010B27 status. This is the first study that investigated the <jats:italic>CCL3L1<\/jats:italic> CNVs in relation to AS risk disease. It reveals that <jats:italic>CCL3L1<\/jats:italic> and <jats:italic>FCGR3B<\/jats:italic> CNVs may not be involved in susceptibility to AS risk in the Algerian population.<\/jats:p>","DOI":"10.1111\/iji.12454","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T10:55:06Z","timestamp":1566384906000},"page":"437-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association study of copy number variants in <i>CCL3L1, FCGR3A<\/i> and <i>FCGR3B<\/i> genes with risk of ankylosing spondylitis in a West Algerian population"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9529-2936","authenticated-orcid":false,"given":"Chahinez Amira","family":"Dahmani","sequence":"first","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire\/Universit\u00e9 des Sciences et de la Technologie d'Oran Mohamed Boudiaf (USTO\u2010MB) Oran Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Benzaoui","sequence":"additional","affiliation":[{"name":"Service de Rhumatologie\/Centre Hospitalo\u2010universitaire d\u2019Oran (CHUO) Oran Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habiba","family":"Amroun","sequence":"additional","affiliation":[{"name":"Laboratoire d\u2019Immunog\u00e9n\u00e9tique et de Transplantation, D\u00e9partement d'Immunologie Institut Pasteur d\u2019Alg\u00e9rie \u00e0 Alger Oran Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faouzia","family":"Zemani\u2010Fodil","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire\/Universit\u00e9 des Sciences et de la Technologie d'Oran Mohamed Boudiaf (USTO\u2010MB) Oran Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9724-3575","authenticated-orcid":false,"given":"Elisabeth","family":"Petit\u2010Teixeira","sequence":"additional","affiliation":[{"name":"GenHotel, University Evry Universit\u00e9 Paris\u2010Saclay Evry France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdallah","family":"Boudjema","sequence":"additional","affiliation":[{"name":"Laboratoire de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire\/Universit\u00e9 des Sciences et de la Technologie d'Oran Mohamed Boudiaf (USTO\u2010MB) Oran Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/860213"},{"issue":"2","key":"e_1_2_6_3_1","first-page":"85","article-title":"Criteria of the classification of spondylarthropathies","volume":"57","author":"Amor B.","year":"1990","journal-title":"Revue Du Rhumatisme Et Des Maladies Ost\u00e9o\u2010Articulaires"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2005.09.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patbio.2012.01.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072047"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-015-3156-y"},{"key":"e_1_2_6_8_1","article-title":"Investigation of candidate gene copy number identifies FCGR3B as a potential biomarker for rheumatoid arthritis","author":"Ben Kilani M. 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