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Growing evidence suggests complex interactions between IFN\u2010\u03b3 and bone remodelling cells. However, potential association of <jats:italic>IFN\u2010\u03b3<\/jats:italic> gene polymorphism with susceptibility to post\u2010traumatic osteomyelitis remains unclear. This study aimed to investigate the potential link between <jats:italic>IFN\u2010\u03b3<\/jats:italic> +874T\/A polymorphism and risk of developing post\u2010traumatic osteomyelitis. A total of 189 patients with post\u2010traumatic osteomyelitis and 200 healthy controls were enrolled for genotyping using the SNaPshot genotyping method. Statistically significant associations were found between the gene polymorphism and the risk of post\u2010traumatic osteomyelitis by dominant model (AA\u00a0+\u00a0AT vs. TT, OR\u00a0=\u00a01.820, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.017) and heterozygous model (AT vs. TT, OR\u00a0=\u00a01.781, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.029). Moreover, the frequency of mutant allele A was significantly higher in the patients than that in the healthy controls (15.07% vs. 9.25%, OR\u00a0=\u00a01.742, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.013). <jats:italic>IFN\u2010\u03b3 <\/jats:italic>+874T\/A polymorphism may contribute to the increased susceptibility to post\u2010traumatic osteomyelitis.<\/jats:p>","DOI":"10.1111\/iji.12462","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T06:39:36Z","timestamp":1574231976000},"page":"163-168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["<i>IFN\u2010\u03b3<\/i> +874T\/A polymorphism increases susceptibility to post\u2010traumatic osteomyelitis"],"prefix":"10.1111","volume":"47","author":[{"given":"Xing\u2010qi","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology Nanfang Hospital Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology Nanfang Hospital Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010jun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology Nanfang Hospital Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3109-2062","authenticated-orcid":false,"given":"Bin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology Nanfang Hospital Southern Medical University Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.niox.2006.06.005"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000155"},{"issue":"3","key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.17305\/bjbms.2016.1232","article-title":"Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis \u2010 a screen of osteoarticular lesions","volume":"16","author":"Bi\u0144czak\u2010Kuleta A.","year":"2016","journal-title":"Bosnian Journal of Basic Medical Sciences"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-09-077438"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-6-82"},{"key":"e_1_2_7_7_1","first-page":"CD004439","article-title":"Antibiotics for treating chronic osteomyelitis in adults","volume":"9","author":"Conterno L. 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