{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:52:28Z","timestamp":1792507948036,"version":"4.5.0"},"reference-count":6,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,23]],"date-time":"2019-12-23T00:00:00Z","timestamp":1577059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Istanbul Medical Faculty, Department of Medical Biology, as the first EFI\u2010accredited HLA laboratory in Turkey since 1999 has been organizing both national and international quality control tests for HLA typing under the banner of the \u201cBalkan external proficiency testing (BEPT)\u201d encompassing countries from EFI regions 8. The first round of BEPT in 2004 was organized for low\u2010resolution HLA\u2010A,\u2010B typing by molecular methods and 12 centres participated in the exercise. In 2005, low\u2010resolution HLA\u2010DR typing was added, and in 2007, low\u2010resolution HLA\u2010C and DQ typing were added to the exercise and 28 centres participated. In 2015, high\u2010resolution (four digits or higher typing) HLA\u2010A,\u2010B,\u2010C,\u2010DR and \u2013DQ typing added to the exercise and 40 centres participated. In the last 2\u00a0years, 2017 and 2018, the number of participating centres increased to 48 and 52, respectively. When the distribution of low\u2010resolution typing methods applied in the exercises were investigated, it was found that 82% of the centres in the first round of BEPT in 2004 used PCR\u2010SSP, whereas in the last round in 2018, 26% of the centres preferred SSP, while the rest used SSO (50%) or SSP and SSO (24%) methods. Methods for high\u2010resolution typing were SBT (41%), NGS (18%), SSO (18%), SSP (6%), SBT\u00a0+\u00a0NGS (6%) and SBT\u00a0+\u00a0SSP (11%). In 15th trial for BEPT, nomenclature mistake rate was 12%, and erroneous result rate was 6% for HLA samples. The most common mistakes in the exercises were nomenclature mistakes. The EFI Standards Version 7.0 is stated \"HLA type can be reported using a hyphen if homozygosity is not proven by family studies.\" In order to provide standard results among HLA laboratories and since accurate HLA typing leads to significant increase of graft and patient survival, quality control exercises should be performed in all HLA\u2010based tests periodically.<\/jats:p>","DOI":"10.1111\/iji.12464","type":"journal-article","created":{"date-parts":[[2019,12,24]],"date-time":"2019-12-24T04:10:35Z","timestamp":1577160635000},"page":"158-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["EFI region 8 Balkan external proficiency testing for HLA typing: Results of 15\u00a0years"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2098-381X","authenticated-orcid":false,"given":"Cigdem","family":"Kekik Cinar","sequence":"first","affiliation":[{"name":"Department of Medical Biology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebahat","family":"Usta Akgul","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonay","family":"Temurhan","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayriye","family":"Senturk Ciftci","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeliz","family":"Ogret","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonca Emel","family":"Karahan","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma Savran","family":"Oguz","sequence":"additional","affiliation":[{"name":"Department of Medical Biology Istanbul Medical Faculty Istanbul University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"113","volume-title":"Focus on immunology research: Standardization of donor\u2010recipient matching in transplantation","author":"Bogunia\u2010Kubik K.","year":"2006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2008.00789.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.07.020"},{"key":"e_1_2_7_5_1","first-page":"99","article-title":"The relevance of proficiency testing for laboratories involved in cadaveric organ transplantation and its consequences for graft survival","volume":"14","author":"Doxiadis I. I.","year":"2000","journal-title":"Clinical Transplantation"},{"key":"e_1_2_7_6_1","volume-title":"Standards for histocompatibility and immunogenetics testing\u2010version 7.0","author":"European Federation for Immunogenetics","year":"2017"},{"key":"e_1_2_7_7_1","volume-title":"Standards for providers of external proficiency testing (EPT) schemes\u2010version 7.2","author":"European Federation for Immunogenetics","year":"2018"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fiji.12464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iji.12464","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T02:10:29Z","timestamp":1694052629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,23]]},"references-count":6,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/iji.12464"],"URL":"https:\/\/doi.org\/10.1111\/iji.12464","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,23]]},"assertion":[{"value":"2019-07-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}