{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:15:57Z","timestamp":1747185357629,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T00:00:00Z","timestamp":1577404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The most important anti\u2010tumour immune response is mediated by T lymphocytes. Cytotoxic T lymphocyte\u2010associated protein 4 (CTLA4) plays a critical role in the immune surveillance against tumours as an inhibitory immune checkpoint molecule of T\u2010cell activation. This study was designed to explore the association of <jats:italic>CTLA4<\/jats:italic> polymorphisms with the susceptibility to oesophageal squamous cell carcinoma (ESCC) and prognosis of patients with ESCC in a high\u2010incidence population from northern China. <jats:italic>CTLA4<\/jats:italic> rs5742909 C\/T and rs231775 G\/A single nucleotide polymorphisms (SNPs) were genotyped using polymerase chain reaction\u2013ligase detection reaction (PCR\u2010LDR) method in 577 ESCC patients and 580 controls. Upper gastrointestinal cancer family history increased the risk of ESCC (the sex\u2010, age\u2010 and smoking status\u2010adjusted OR\u00a0=\u00a01.383, 95%CI\u00a0=\u00a01.094\u20131.749). The genotype frequencies of these two SNPs in the patients with ESCC were similar to that in the controls. Survival analyses were conducted in 204 patients with ESCC with five\u2010year survival information. The mean survival time of ESCC patients with rs231775 SNP A\/A genotype in age over 60\u00a0years group was 23.2\u00a0months, significantly shorter than that of those with G\/G genotype (47.3\u00a0months). The A\/A genotype was associated with increased death risk of patients with ESCC older than 60\u00a0years (adjusted HR\u00a0=\u00a04.544, 95%CI\u00a0=\u00a01.913\u201310.790). <jats:italic>CTLA4<\/jats:italic> rs231775 SNP might be used as genetic marker of worse prognosis for patients with ESCC over 60\u00a0years in a high\u2010incidence population from northern China.<\/jats:p>","DOI":"10.1111\/iji.12470","type":"journal-article","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T05:32:40Z","timestamp":1577511160000},"page":"180-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of cytotoxic T\u2010lymphocyte associated protein 4 gene polymorphisms with the risk and prognosis of oesophageal cancer in a high\u2010incidence region from northern China"],"prefix":"10.1111","volume":"47","author":[{"given":"Lei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery The Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Hebei Provincial Cancer Institute The Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Hebei Provincial Cancer Institute The Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Huang","sequence":"additional","affiliation":[{"name":"Hebei Provincial Cancer Institute The Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi\u2010Ru","family":"Cao","sequence":"additional","affiliation":[{"name":"Hebei Provincial Cancer Institute The Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7084-0916","authenticated-orcid":false,"given":"Rong\u2010Miao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Hebei Provincial Cancer Institute The Fourth Hospital of Hebei Medical University Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1663-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/35105024"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.1.144"},{"volume-title":"The screening value of immune\u2010related gene and metabolic\u2010related gene detection for Kazakh\u2019s esophageal cancer in xinjiang","year":"2011","author":"Cai J.","key":"e_1_2_7_5_1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1506-4"},{"key":"e_1_2_7_7_1","first-page":"432","article-title":"Haplotype analysis of CTLA4 gene and risk of esophageal squamous cell carcinoma in Anyang area of China","volume":"58","author":"Cheng X. 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