{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:48:27Z","timestamp":1779911307342,"version":"3.53.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,16]],"date-time":"2020-02-16T00:00:00Z","timestamp":1581811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increasing evidence on the association of <jats:italic>MTHFR<\/jats:italic> gene polymorphism and serum homocysteine levels with autoimmune diseases such as vitiligo has made the <jats:italic>MTHFR<\/jats:italic> gene a very interesting candidate to be evaluated in different ethnicities and populations. We aimed to evaluate the levels of serum homocysteine and vitamin B12 and their associations with <jats:italic>MTHFR C677T<\/jats:italic> polymorphism in the Iranian population. This case\u2013control study included 104 patients with vitiligo and 100 age\u2010 and sex\u2010matched healthy control subjects. Serum vitamin B12 and homocysteine levels were measured by a chemiluminescence assay. Polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP) analysis was used for genotyping the polymorphism. The mean serum homocysteine levels were significantly higher in cases than controls and associated with disease activity (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Furthermore, the homozygous <jats:italic>MTHFR<\/jats:italic> C677T variant genotype was associated with vitiligo development (adjusted OR: 3.52, 95% CI: 1.09\u201311.32, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) and elevated homocysteine level (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). There was no association between serum vitamin B12 levels and the <jats:italic>MTHFR C677T<\/jats:italic> genotype. The homozygous variant <jats:italic>MTHFR<\/jats:italic> C677T may be considered as a risk factor for both elevated homocysteine levels and the development of vitiligo in the Iranian population. Although these results are not conclusive, they could elucidate the contribution of genetic and immune\u2010mediated inflammatory factors to the pathogenesis of vitiligo.<\/jats:p>","DOI":"10.1111\/iji.12476","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T04:49:31Z","timestamp":1581914971000},"page":"342-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association of <i>MTHFR C677T<\/i> polymorphism with elevated homocysteine level and disease development in vitiligo"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2043-0705","authenticated-orcid":false,"given":"Arash","family":"Bagheri Hamidi","sequence":"first","affiliation":[{"name":"Skin Research Center Shahid Beheshti University of Medical Sciences Tehran 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