{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:15:59Z","timestamp":1747185359266,"version":"3.40.5"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","doi-asserted-by":"publisher","award":["APQ\u20100296\u20104.01\/08"],"award-info":[{"award-number":["APQ\u20100296\u20104.01\/08"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Single nucleotide polymorphisms (SNPs) in immune\u2010related genes have been shown to play a role in driving the development of the severe phenotypes of dengue virus (DENV) infection. We assessed the association between <jats:italic>IFNL3<\/jats:italic> gene SNP (rs12979860) and dengue clinical outcomes in children. Patients with dengue\u2010related symptoms (aged 1\u201315\u00a0years) admitted at a public hospital in Northeast Brazil were invited to participate. The association between rs12979860 polymorphism and dengue classification and clinical signs and symptoms were analysed. A total of 206 DENV\u2010infected children were included: 53.4% of the infections were classified as severe dengue. The T allele carriers had higher risk of developing severe dengue when compared to CC genotype carriers (OR: 1.81; 95% CI: 0.98\u20133.32 <jats:italic>p<\/jats:italic>\u00a0=\u00a0.054). The T allele carriers also showed longer fever episodes when compared to patients with the CC genotype (OR: 1.90; 95%CI: 1.07\u20133.38; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.027). On the other hand, the ones carrying the CT\/TT genotype had 70% lower chance of developing thrombocytopenia when compared to those with the CC genotype (OR: 0.30; 95%CI: 0.08\u20130.88; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.042). Our findings demonstrated that the T allele carriers of the <jats:italic>IFNL3<\/jats:italic> gene had higher risk of developing severe dengue, suggesting a link between IFN\u2010\u03bb expression and DENV immunopathogenesis.<\/jats:p>","DOI":"10.1111\/iji.12477","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T11:53:54Z","timestamp":1581940434000},"page":"351-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between interferon lambda 3 rs12979860 polymorphism and clinical outcome in dengue virus\u2010infected children"],"prefix":"10.1111","volume":"47","author":[{"given":"Renata Duarte","family":"da Silva Cezar","sequence":"first","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas Universidade de Pernambuco Recife Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila Mayrelle","family":"da Silva Castanha","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas Universidade de Pernambuco Recife Brasil"},{"name":"Instituto Aggeu Magalh\u00e3es Funda\u00e7\u00e3o Oswaldo Cruz Recife Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naishe","family":"Matos Freire","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas Universidade de Pernambuco Recife Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Mola","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biol\u00f3gicas Universidade de Pernambuco Recife Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Feliciano do Carmo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco\u2010UNIVASF Petrolina Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marli","family":"Ten\u00f3rio Cordeiro","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es Funda\u00e7\u00e3o Oswaldo Cruz Recife Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo","family":"Baptista","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas Universidade de Pernambuco Recife Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1625-3358","authenticated-orcid":false,"given":"Luydson Richardson","family":"Silva Vasconcelos","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas Universidade de Pernambuco Recife Brasil"},{"name":"Instituto Aggeu Magalh\u00e3es Funda\u00e7\u00e3o Oswaldo Cruz Recife Brasil"},{"name":"Instituto do F\u00edgado Recife 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