{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:27:57Z","timestamp":1789165677781,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Identification of candidate genes associated with susceptibility of breast cancer can have a significant impact at a cancer management national healthcare systems level, making genetic testing more affordable and cost\u2010effective. We have previously shown that the major histocompatibility complex class I\u2010related chain A (MICA) was related to breast cancer and plays an important role in modulating immune response mechanisms through NKG2D receptor activation. Compared to our previous study, in this work, we recruited a new cohort composed of 354 unrelated Tunisian women affected by breast cancer and 380 age\u2010matched women as controls, all genotyped for MICA\u2010129 Met\/Val (rs 1051792). Subsequently, we exanimated the distribution of this polymorphism in ten families. As a result, an association was found between the Val allele and Val\/Val genotype and the risk of breast cancer (<jats:italic>p<\/jats:italic>\u00a0=\u00a02.5\u00a0\u00d7\u00a010<jats:sup>\u201315<\/jats:sup>; OR\u00a0=\u00a02.40; <jats:italic>p<\/jats:italic>\u00a0=\u00a06.5\u00a0\u00d7\u00a010<jats:sup>\u201313<\/jats:sup>; OR\u00a0=\u00a03.03, respectively). Stratified analysis with age and family history of cancer revealed an association between the Val\/Val genotype and younger patients &lt;40\u00a0years (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.003; OR\u00a0=\u00a02.03). Among those patients having a family history of cancer, 68% had a Val\/Val genotype (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02; OR\u00a0=\u00a01.82). In the family study, an analyse of pedigrees revealed that the majority of families showed the development of breast cancer at a young age. Moreover, all patients diagnosed with early\u2010onset breast cancer had a Val\/Val genotype. Our results lead us to propose that this polymorphism may be an inherited genetic biomarker contributing to an increased breast cancer risk in Tunisian women.<\/jats:p>","DOI":"10.1111\/iji.12480","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T04:41:36Z","timestamp":1581482496000},"page":"406-413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>MICA<\/i>\u2010129 Met\/Val polymorphism could be a genetic biomarker for Familial Breast Cancer in the Tunisian population"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3591-6196","authenticated-orcid":false,"given":"Nesrine","family":"Ouni","sequence":"first","affiliation":[{"name":"Clinical Biology Department Salah Azaiz Institut Tunis Tunisia"},{"name":"Faculty of Mathematics, Physics and Natural Sciences University of Tunis El Manar Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arij","family":"Ben Chaaben","sequence":"additional","affiliation":[{"name":"Clinical Biology Department Salah Azaiz Institut Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayza","family":"Ayari","sequence":"additional","affiliation":[{"name":"Clinical Biology Department Salah Azaiz Institut Tunis Tunisia"},{"name":"Faculty of Mathematics, Physics and Natural Sciences University of Tunis El Manar Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0559-9940","authenticated-orcid":false,"given":"Hayet","family":"Douik","sequence":"additional","affiliation":[{"name":"Clinical Biology Department Salah Azaiz Institut Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Guizani","sequence":"additional","affiliation":[{"name":"Faculty of Mathematics, Physics and Natural Sciences University of Tunis El Manar Tunis Tunisia"},{"name":"Faculty of Medicine of Tunis CHU la Rabta Laboratory of Biochemistry Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amel","family":"Benammar\u2010Elgaaied","sequence":"additional","affiliation":[{"name":"Immunology Department Faculty of Mathematics, Physics, and Natural Sciences Tunis El Manar University Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fethi","family":"Guemira","sequence":"additional","affiliation":[{"name":"Clinical Biology Department Salah Azaiz Institut Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryad","family":"Tamouza","sequence":"additional","affiliation":[{"name":"INSERM U955 Translational Psychiatry Creteil France"},{"name":"Fondation FondaMental Creteil France"},{"name":"Department of Psychiatry AP\u2010HP DHU PePSY H\u00f4pital Henri Mondor Universit\u00e9 Paris\u2010Est\u2010Creteil Creteil France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5195\/CAJGH.2016.228"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-13-0340"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2005.09.004"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2014.02.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2017.1404635"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5428.727"},{"issue":"10","key":"e_1_2_7_8_1","first-page":"2963","article-title":"BRCA1\/BRCA2 mutations shaped by ancient consanguinity practice in southern mediterranean populations","volume":"19","author":"Belaiba F.","year":"2018","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2349"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-217430"},{"key":"e_1_2_7_11_1","article-title":"MHC class I chain\u2010related gene diversity in patients with cutaneous malignant melanoma from Southeastern Spain","author":"Campillo J. 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