{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:50:26Z","timestamp":1787503826559,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Epithelial ovarian cancer (EOC) contributes the majority of death cases among various ovarian malignancies. Although a standard method of treatment is the surgical removal of malignant tissue followed by platinum\u2010based chemotherapy, a group of patients does not respond appropriately to cisplatin. An appropriate response to cisplatin has been linked with the nucleotide excision repair mechanism. The present study aims to investigate the role of polymorphisms in DNA repair genes, excision repair cross\u2010complementation group 1 (ERCC1) with susceptibility to EOC development and tumour response to platinum\u2010based chemotherapy in Chinese EOC patients. Patients (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0559) reporting to the Department of Oncology and general surgery, the First Affiliated Hospital of Kunming Medical University, were enrolled in the study. Three hundred twenty\u2010three healthy controls hailing from similar geographical areas without a history of cancer enrolled as healthy controls. Excision repair cross\u2010complementation group 1 polymorphisms (rs11615, rs3212986, rs735482, rs2336219, rs3212980, rs3212964, rs3212961 and rs2298881) were genotyped by appropriate methods. Distribution of genotypes and allele for ERCC1 polymorphisms (rs11615, rs3212986, rs735482, rs2336219, rs3212980, rs3212964, rs3212961 and rs2298881) were comparable among healthy controls and EOC patients. Interestingly, homozygous mutant and the minor allele for rs11615 and rs3212986 polymorphisms were significantly higher in nonresponder EOC patients when compared to those with a proper response to cisplatin treatment. The prevalence of other SNPs was comparable among the two treated clinical categories. Furthermore, combined genotype revealed significant association of rs11615: TT\/ rs3212986: AA genotype combination with cisplatin nonresponder. Variants of rs11615, rs3212986 polymorphisms are associated with cisplatin resistance in Chinese EOC patients. Combined rs11615 and rs3212986 genotypes can be used as a predictive biomarker for platinum\u2010based chemotherapy outcomes.\n                  <\/jats:p>","DOI":"10.1111\/iji.12484","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T04:35:51Z","timestamp":1584333351000},"page":"443-453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Role of common ERCC1 polymorphisms in cisplatin\u2010resistant epithelial ovarian cancer patients: A study in Chinese cohort"],"prefix":"10.1111","volume":"47","author":[{"given":"Yuxia","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The First Affiliated Hospital of Kunming Medical University Kunming China"},{"name":"Yunnan Institute of Experimental Diagnosis Kunming China"},{"name":"Yunnan Key Laboratory of Laboratory Medicine Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital of Kunming Medical University Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjiao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oncology The First Affiliated Hospital of Kunming Medical University Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Pain treatment The First Affiliated Hospital of Kunming Medical University Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2138-1570","authenticated-orcid":false,"given":"Jianyuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital of Kunming Medical University Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3821"},{"issue":"5","key":"e_1_2_5_3_1","first-page":"516","article-title":"The prognostic and predictive value of ERCC\u20101, p53, bcl\u20102 and bax in epithelial ovarian cancer","volume":"32","author":"Avraam K.","year":"2011","journal-title":"European Journal of Gynaecological Oncology"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl435"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.01.005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(99)00020-2"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.9688"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1525\/ae.2004.31.4.475"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2013.5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/84.19.1512"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117388"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.07.025"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.5528\/wjtm.v3.i1.1"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.07.001"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.01.014"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2012.13.5.1799"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00051338"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-04-1387"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-9966-31-14"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2009.20.2.72"},{"issue":"9","key":"e_1_2_5_21_1","first-page":"3223","article-title":"Multiple roles of the ERCC1\u2010XPF endonuclease in DNA repair and resistance to anticancer drugs","volume":"30","author":"Kirschner K.","year":"2010","journal-title":"Anticancer Research"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1323"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2013.14.12.7203"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2014.882414"},{"issue":"7","key":"e_1_2_5_25_1","first-page":"2286","article-title":"Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non\u2010small cell lung cancer","volume":"8","author":"Lord R. 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