{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:18:20Z","timestamp":1792793900926,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cervical cancer (CCa) is one of the most common malign diseases in women associated with human papillomavirus (HPV). The virus is an initiating factor, but not sufficient for the development of cervical intraepithelial lesions (CIN) and CCa. The disease might be a result of the influence of host's genetic factors and polymorphisms in inflammatory\u2010related genes that modify the immune response to HPV and attribute to cancer susceptibility. We carried out a study to determine the association between TNF\u2010a\u2010238G\/A and TNF\u2010a\u2010308 G\/T polymorphisms with HPV\u2010positive CIN and CCa in women living in the Republic of North Macedonia. Using multiplex SNaPshot analysis for single nucleotide polymorphisms (SNPs), we analysed the genotype and allele distributions of TNF\u2010a\u2010238G\/A and TNF\u2010a\u2010308 G\/T in 134 cases (HPV\u2010positive and histologically confirmed CIN and CCa) and in 113 controls (cytological and HPV\u2010negative women). For further analysis, the case group was stratified in three subgroups (all cases: CINs+ CCa\u2212 group; CIN2+ \u2010group and CIN1\u2212 group). Data analysed using the odds ratio (OR) and chi\u2010square test showed the frequency of AA genotypes and A alleles are not significantly higher in cases compared to the controls for both SNPs: AA of TNF\u2010a\u2010238 (0.7% versus 0%) and TNF\u2010a\u2010308 (1.5% versus 0.9%) as well as A allelic frequency (3.0% versus 1.7%) and (13.1% versus 10.6), respectively. The comparison of the case's subgroups with the control group did not show a statistically significant difference. Compared to controls, TNF\u2010a\u2010238G\/A and TNF\u2010a\u2010308 G\/T are not associated with the risk of HPV associated CIN or CCa in the studied women.<\/jats:p>","DOI":"10.1111\/iji.12506","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T08:55:01Z","timestamp":1594716901000},"page":"522-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association of <i>TNF<\/i>\u2010a (rs361525 and rs1800629) with susceptibility to cervical intraepithelial lesion and cervical carcinoma in women from Republic of North Macedonia"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8587-7386","authenticated-orcid":false,"given":"Sotirija","family":"Duvlis","sequence":"first","affiliation":[{"name":"Department of Virology and Molecular Diagnostics Institute of Public Health of North Macedonia Skopje Republic of North Macedonia"},{"name":"Faculty of Medical Sciences Stip Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drage","family":"Dabeski","sequence":"additional","affiliation":[{"name":"University Clinic for Gynecology and Obstetrics University \u201cSs. Cyril and Methodius\u201d Skopje Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8827-0245","authenticated-orcid":false,"given":"Aleksandar","family":"Cvetkovski","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences Stip Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2503-4699","authenticated-orcid":false,"given":"Kristina","family":"Mladenovska","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy University \u201cSs. Cyril and Methodius\u201d Skopje Republic of North Macedonia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8877-2416","authenticated-orcid":false,"given":"Dijana","family":"Plaseska\u2010Karanfilska","sequence":"additional","affiliation":[{"name":"Research Centre for Genetic Engineering and Biotechnology Academy of Sciences and Arts Skopje Republic of North 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