{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T16:31:26Z","timestamp":1768840286415,"version":"3.49.0"},"reference-count":41,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The published evidences on the correlations of <jats:italic>toll\u2010like receptor 4<\/jats:italic> (<jats:italic>TLR4<\/jats:italic>) and <jats:italic>TLR9<\/jats:italic> gene polymorphisms and ankylosing spondylitis (AS) were conflicting. The purpose of this study was to investigate whether <jats:italic>TLR4<\/jats:italic> and <jats:italic>TLR9<\/jats:italic> gene polymorphisms conferred susceptibility to AS through a meta\u2010analysis approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Databases of PubMed, Web of Science, EMBASE, Cochrane Library, CNKI and Wanfang were retrieved for relevant publications up to 20 June 2020. Study quality was assessed based on Newcastle\u2010Ottawa scale (NOS). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to judge the associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Totally, 13 articles with 3,055 AS cases and 4,238 controls were incorporated into this meta\u2010analysis, and four most widely reported polymorphisms (<jats:italic>TLR4\u2010rs4986790<\/jats:italic>, <jats:italic>TLR4\u2010rs4986791<\/jats:italic>, <jats:italic>TLR9\u2010rs55704465<\/jats:italic> and <jats:italic>TLR9\u2010rs187084<\/jats:italic>) were analysed. All included studies were in high quality. The pooled data did not support any significant association between the four studied polymorphisms and AS susceptibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present meta\u2010analysis suggests there is no significant association between <jats:italic>TLR4\u2010rs4986790<\/jats:italic>, <jats:italic>TLR4\u2010rs4986791<\/jats:italic>, <jats:italic>TLR9\u2010rs55704465<\/jats:italic> and <jats:italic>TLR9\u2010rs187084<\/jats:italic> polymorphisms and AS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iji.12524","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T22:52:07Z","timestamp":1608850327000},"page":"219-228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Associations of <i>toll\u2010like receptor 4<\/i> and <i>2<\/i> gene polymorphisms with susceptibility to ankylosing spondylitis: A meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"given":"Shutao","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Spine Surgery Xinjiang Medical University First Affiliated Hospital Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Xinjiang Medical University First Affiliated Hospital Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Xinjiang Medical University First Affiliated Hospital Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanhui","family":"Xun","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Xinjiang Medical University First Affiliated Hospital Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Xinjiang Medical University First Affiliated Hospital Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Xinjiang Medical University First Affiliated Hospital Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weidong","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Xinjiang Medical University First Affiliated Hospital Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-3221","authenticated-orcid":false,"given":"Weibin","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery Xinjiang Medical University First Affiliated Hospital Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.045476"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/opo.12131"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100469"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00297-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2015.133"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.11.883"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.17"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8473-z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket387"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60071-8"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102496"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13795"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel062"},{"issue":"4","key":"e_1_2_11_15_1","first-page":"11","article-title":"ERAP\u20101, TLR\u20109 and TGF\u2010\u03b21 gene polymorphisms and their associations with ankylosing spondylitis","volume":"13","author":"Guo J. 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