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Two single nucleotide polymorphisms (SNPs) of B7\u2010H3 gene and three SNPs of B7\u2010H4 gene were genotyped in 649 AS patients and 646 age\u2010 and sex\u2010matched healthy controls. Allele, genotype frequencies and different inheritance models were performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs), and the demographic and clinical parameters of patients were recorded. Our data indicated that B7\u2010H4 rs10801935 and rs3738414 polymorphisms were correlated with AS susceptibility. In the stratification analyses, the minor A allele and GA genotype of B7\u2010H4 rs3738414 increased the risk of AS in male patients (OR = 1.244, 95%CI = 1.026\u20131.508; OR = 1.453, 95%CI = 1.120\u20131.886, respectively). However, the association did not reach statistical significance after Bonferroni correction. Furthermore, haplotype analysis revealed that B7\u2010H4 haplotype block TAG was a risk factor for the onset of AS (OR = 1.190, 95%CI = 1.020\u20131.389). These findings suggested that B7\u2010H4 gene polymorphism may contribute to AS susceptibility in eastern Chinese Han population.<\/jats:p>","DOI":"10.1111\/iji.12559","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T20:15:05Z","timestamp":1632428105000},"page":"500-509","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association analysis of B7\u2010H3 and B7\u2010H4 gene single nucleotide polymorphisms in susceptibility to ankylosing spondylitis in eastern Chinese Han population"],"prefix":"10.1111","volume":"48","author":[{"given":"Yuting","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Anhui Medical University  Hefei Anhui China"},{"name":"The Key Laboratory of Major Autoimmune Diseases Anhui Medical University  Hefei Anhui 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