{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T20:27:59Z","timestamp":1781900879675,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81160197"],"award-info":[{"award-number":["81160197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Host immune system genes play key roles in the progression of chronic hepatitis C virus (HCV) infection. Transporters associated with antigen processing (TAP) play an important role in the loading of viral peptides onto MHC class I molecules. This study aimed to investigate the association between <jats:italic>TAP<\/jats:italic> gene polymorphisms and chronic HCV in a Chinese Han population. A total of 232 chronic hepatitis C (CHC) patients and 362 healthy individuals were recruited from the Han population in Yunnan province in southwest China, and a TaqMan SNP genotyping assay was used to detect six single nucleotide polymorphisms (SNPs) of <jats:italic>TAP1<\/jats:italic> and three SNPs of <jats:italic>TAP2<\/jats:italic> genes. The association of the <jats:italic>TAP<\/jats:italic> gene with CHC was analysed at the allele, genotype, and haplotype levels. There were no significant differences in the allele and genotype frequencies of these SNPs in the <jats:italic>TAP<\/jats:italic> gene between CHC patients and controls after Bonferroni correction. A novel <jats:italic>TAP1<\/jats:italic> allele (<jats:italic>TAP1*unknown_1<\/jats:italic>: rs41555220\u2010rs41549617\u2010rs1057141\u2010rs1135216\u2010rs1057149\u2010rs41551515: G\u2010G\u2010A\u2010G\u2010G\u2010G) was only present in the CHC group, and this allele significantly increased susceptibility to CHC (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.005, odds ratio [OR]\u00a0=\u00a011.105. 95% confidence interval [CI]: 1.362\u201390.558). Homozygous <jats:italic>TAP1*03:01\/TAP1*03:01<\/jats:italic> was observed only in the CHC group that exhibited an obvious risk for CHC (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.002, OR\u00a0=\u00a09.637, 95% CI: 1.153\u201380.574). And the haplotype <jats:italic>TAP1*unknown_1\u2010TAP2*01:01<\/jats:italic> was only present in the CHC group and indicated a significant risk for CHC (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.002, OR\u00a0=\u00a09.498, 95% CI: 1.140\u201379.149). We observed significant interactions among <jats:italic>HLA\u2010A<\/jats:italic>, <jats:italic>\u2010B<\/jats:italic>,<jats:italic>C<\/jats:italic>, <jats:italic>TAP1<\/jats:italic>, and <jats:italic>TAP2<\/jats:italic> alleles, and combination analysis revealed that the combination of <jats:italic>TAP1*01:01\u2010TAP2*01:01\u2010HLA\u2010B*35:01<\/jats:italic> was only present in the control group (2.2%) and resulted in significantly increased resistance to CHC (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.002, OR\u00a0=\u00a00.096, 95% CI: 0.012\u20130.759). Whereas, the combination of <jats:italic>TAP1*01:01\u2010TAP2*01:01\u2010HLA\u2010C*07:02<\/jats:italic> and <jats:italic>TAP1*03:01\u2010TAP2*01:01\u2010HLA\u2010C*01:02<\/jats:italic> increased the susceptibility to CHC significantly (<jats:italic>p\u00a0<\/jats:italic>=\u00a0.001, OR\u00a0=\u00a02.016, 95% CI: 1.309\u20133.106 and <jats:italic>p\u00a0<\/jats:italic>=\u00a0.002, OR\u00a0=\u00a08.070, 95% CI: 1.018\u201363.997, respectively). Our results indicated that TAP and HLA\u2010I may exert a combined effect on CHC susceptibility in the Chinese Han population.<\/jats:p>","DOI":"10.1111\/iji.12574","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T10:08:06Z","timestamp":1651226886000},"page":"169-180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association study of <i>TAP<\/i> and <i>HLA\u2010I<\/i> gene combination with chronic hepatitis C virus infection in a Han population in China"],"prefix":"10.1111","volume":"49","author":[{"given":"Yufen","family":"Tao","sequence":"first","affiliation":[{"name":"Institute of Medical Biology Chinese Academy of Medical Sciences &amp; Peking Union Medical College Yunnan Key Laboratory of Vaccine Research &amp; Development on Severe Infectious Disease  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Immunogenetics Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nannan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Immunogenetics Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology Chinese Academy of Medical Sciences &amp; Peking Union Medical College Yunnan Key Laboratory of Vaccine Research &amp; Development on Severe Infectious Disease  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9508-7863","authenticated-orcid":false,"given":"Li","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Immunogenetics Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5691-8510","authenticated-orcid":false,"given":"Shuyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Immunogenetics Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Yao","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology Chinese Academy of Medical Sciences &amp; Peking Union Medical College Yunnan Key Laboratory of Vaccine Research &amp; Development on Severe Infectious Disease  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200300642"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-9946202163055"},{"issue":"12","key":"e_1_2_7_4_1","first-page":"2670","article-title":"Guidelines for the prevention and treatment of chronic hepatitis C (2019 version)","volume":"35","author":"Chinese Society of Hepatology, C. 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