{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T17:41:57Z","timestamp":1692898917429},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several single nucleotide polymorphisms (SNPs) associated with susceptibility to Hodgkin lymphoma (HL) and diffuse large B\u2010cell lymphoma (DLBCL) have been identified. The aim of this study was to identify susceptibility loci for HL and DLBCL in Polish patients. Altogether, DLBCL (<jats:italic>n<\/jats:italic>\u00a0=\u00a0218 and HL patients (<jats:italic>n<\/jats:italic>\u00a0=\u00a0224) and healthy individuals (<jats:italic>n<\/jats:italic>\u00a0=\u00a01181) were recruited. Lymphoma diagnosis was based on standard criteria. Genome\u2010wide association study (GWAS) was performed using pooled\u2010DNA samples on llumina Infinium Omni2.5 Exome\u20108 v1.3, and selected loci were replicated by TaqMan SNP genotyping of individuals. GWAS detected thirteen and seven SNPs associated with DLBCL and HL, respectively. In the replication study, six and seven SNPs reached significance after correction for multiple testing in the DLBCL and HL cohorts, respectively. One and four SNPs associated with DLBCL and HL, respectively, were localized within, and two SNPs\u2014near the major histocompatibility complex (MHC) region. In conclusion, the majority of loci associated with HL and DLBCL aetiology in previous studies have potential roles in immune function. Our pooled\u2010DNA GWAS enabled the identification of several susceptibility loci for DLBCL and HL in the Polish population; some of them were mapped within or adjacent to the MHC, and other associated SNPs were located outside the MHC.<\/jats:p>","DOI":"10.1111\/iji.12596","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T13:59:37Z","timestamp":1661781577000},"page":"353-363","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic associations with lymphomas in Polish patients: A pooled\u2010DNA genome\u2010wide association analysis"],"prefix":"10.1111","volume":"49","author":[{"given":"Ewa","family":"Paszkiewicz\u2010Kozik","sequence":"first","affiliation":[{"name":"Department of Lymphoproliferative Diseases Maria Sklodowska\u2010Curie National Research Institute of Oncology  Warsaw 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