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LILRBs are widely expressed in bone marrow cells, hematopoietic stem cells, nerve cells and other body cells. Studies have found that LILRBs receptor can bind to a variety of ligands and has a variety of biological functions such as regulating inflammatory response, immune tolerance and cell differentiation. Inflammatory reaction plays a vital role in resisting microorganisms. The function of inhibitory immune receptors can recognize the signs of infection and promote the function of anti\u2010microbial effect. The inflammatory response must be strictly regulated to prevent excessive inflammation and tissue damage. Therefore, it is of general interest to understand the role of LILRBs in the inflammatory response. Because they can inhibit the anti\u2010microbial response of neutrophils, some human pathogens use these receptors to escape immunity. This article reviews the biological role of LILRBs in the inflammatory response. 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Here, we describe in detail the regulation of LILRBs on the inflammatory response, its signal transduction mode in inflammation, and the progress in the treatment of inflammatory diseases, providing a reference for further research.<\/jats:p>","DOI":"10.1111\/iji.12618","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T04:06:17Z","timestamp":1681185977000},"page":"107-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Research progress of B subfamily of leucocyte immunoglobulin\u2010like receptors in inflammation"],"prefix":"10.1111","volume":"50","author":[{"given":"Mengting","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First College of Clinical Medical Science China Three Gorges University &amp; Yichang Central People's Hospital  Yichang Hubei China"},{"name":"Institute of Cardiovascular Diseases China Three Gorges University  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