{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:16:16Z","timestamp":1747185376922,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T00:00:00Z","timestamp":1690070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The association between <jats:italic>HLA<\/jats:italic> loci and haematological malignancy has been reported in certain populations. However, there are limited data for <jats:italic>HLA<\/jats:italic> loci at a high\u2010resolution level with haematological malignancy in China. In this study, a total of 1115 patients with haematological malignancies (including 490 AML, 410 acute lymphoblastic leukaemia (ALL), 122 myelodysplastic syndrome [MDS] and 93 non\u2010Hodgkin's lymphoma [NHL]) and 1836 healthy individuals as a control group in the Han population of Zhejiang Province, China, were genotyped for <jats:italic>HLA\u2010A<\/jats:italic>, <jats:italic>HLA\u2010C<\/jats:italic>, <jats:italic>HLA\u2010B<\/jats:italic>, <jats:italic>HLA\u2010DRB1<\/jats:italic> and <jats:italic>HLA\u2010DQB1<\/jats:italic> loci at high resolution. The possible association between <jats:italic>HLA<\/jats:italic> alleles and haplotypes and haematologic malignancy was analysed. The allele frequencies (AFs) of <jats:italic>HLA\u2010A*02:05<\/jats:italic>, <jats:italic>HLA\u2010A*02:06<\/jats:italic>, <jats:italic>HLA\u2010A*32:01<\/jats:italic>, <jats:italic>HLA\u2010B*35:03<\/jats:italic>, <jats:italic>HLA\u2010B*54:01<\/jats:italic>, <jats:italic>HLA\u2010B*55:07<\/jats:italic>, <jats:italic>HLA\u2010DRB1*04:05<\/jats:italic>, <jats:italic>HLA\u2010DRB1*15:01<\/jats:italic>, <jats:italic>HLA\u2010DQB1*04:01<\/jats:italic> and <jats:italic>HLA<\/jats:italic>\u2010<jats:italic>DQB1*06:02<\/jats:italic> in the MDS patients were much higher than those in the control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), while the AFs of <jats:italic>HLA\u2010C*07:02<\/jats:italic>, <jats:italic>HLA\u2010DRB1*03:01<\/jats:italic>, <jats:italic>HLA\u2010DRB1*14:54<\/jats:italic>, <jats:italic>HLA\u2010DQB1*02:01<\/jats:italic> and <jats:italic>HLA\u2010DQB1*05:03<\/jats:italic> were obviously lower than those in the control group (<jats:italic>p<\/jats:italic> &lt; .05). Interestingly, the differences in these <jats:italic>HLA<\/jats:italic> alleles in patients with MDS were not significant after applying Bonferroni correction (<jats:italic>Pc<\/jats:italic>\u00a0&gt;\u00a0.05), except for <jats:italic>HLA\u2010A*02:06<\/jats:italic> (<jats:italic>Pc<\/jats:italic>\u00a0&lt;\u00a0.01). There were 13, 6 and 10 <jats:italic>HLA<\/jats:italic> alleles with uncorrected significant differences (<jats:italic>p<\/jats:italic> &lt; .05) among patients with AML, ALL and NHL, respectively, compared with those in the control group, but the differences in these <jats:italic>HLA<\/jats:italic> alleles were not significant after correction (<jats:italic>Pc<\/jats:italic>\u00a0&gt;\u00a0.05). Compared to those of the control group, there were some haplotypes over 1.00% frequency in patients with AML, MDS and NHL patients with uncorrected significant differences (<jats:italic>p<\/jats:italic> &lt; .05). However, none of them showed a significant difference after correction as well (<jats:italic>Pc<\/jats:italic>\u00a0&gt;\u00a0.05). The study reveals that <jats:italic>HLA\u2010A*02:06<\/jats:italic> may lead to susceptibility to MDS, but none of the <jats:italic>HLA<\/jats:italic> alleles were associated with AML, ALL or NHL after correction. These data will help to further understand the role of <jats:italic>HLA<\/jats:italic> loci in the pathogenesis of haematological malignancy in China.<\/jats:p>","DOI":"10.1111\/iji.12629","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T01:58:22Z","timestamp":1690163902000},"page":"233-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>HLA\u2010A*02:06<\/i> allele may be susceptible to myelodysplastic syndrome in Zhejiang Han population, China"],"prefix":"10.1111","volume":"50","author":[{"given":"Nanying","family":"Chen","sequence":"first","affiliation":[{"name":"HLA Typing Laboratory Blood Center of Zhejiang Province Hangzhou China"},{"name":"HLA Typing Laboratory Key Laboratory of Blood Safety Research of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-8899","authenticated-orcid":false,"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory Blood Center of Zhejiang Province Hangzhou China"},{"name":"HLA Typing Laboratory Key Laboratory of Blood Safety Research of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanmin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center the First Affiliated Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6791-7871","authenticated-orcid":false,"given":"Lina","family":"Dong","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory Blood Center of Zhejiang Province Hangzhou China"},{"name":"HLA Typing Laboratory Key Laboratory of Blood Safety Research of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory Blood Center of Zhejiang Province Hangzhou China"},{"name":"HLA Typing Laboratory Key Laboratory of Blood Safety Research of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory Blood Center of Zhejiang Province Hangzhou China"},{"name":"HLA Typing Laboratory Key Laboratory of Blood Safety Research of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"He","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory Blood Center of Zhejiang Province Hangzhou China"},{"name":"HLA Typing Laboratory Key Laboratory of Blood Safety Research of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1963-9176","authenticated-orcid":false,"given":"Faming","family":"Zhu","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory Blood Center of Zhejiang Province Hangzhou China"},{"name":"HLA Typing Laboratory Key Laboratory of Blood Safety Research of Zhejiang Province Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102016\u201003\u2010643544"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.199"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12411"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/tan.13885"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010008\u20100040\u20104"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.143"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755\u20100998.2010.02847.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/705862"},{"key":"e_1_2_9_10_1","first-page":"210","article-title":"Study on the correlation between acute lymphoblastic leukemia and HLA genes in southern China Han population","volume":"13","author":"Gao S. 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