{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:56:59Z","timestamp":1788195419431,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Objective: Rheumatoid factor (RF) and anti\u2010cyclic citrullinated peptide antibody (anti\u2010CCP) are commonly used for diagnosis of rheumatoid arthritis (RA), although other rheumatic diseases with arthritis can test positive. This study aimed to determine the cutoff values for RF and anti\u2010CCP with the best diagnostic performance in a sample of patients with RA, compared with other rheumatic diseases.<\/jats:p>\n                    <jats:p>Methods: This was a descriptive, prospective study. EUROINMMUN enzyme\u2010linked immunosorbent assays for RF isotypes immunoglobulin (Ig) A (IgA), IgG and IgM and third\u2010generation assay IgG for anti\u2010CCP were used in serum samples of patients with RA, other rheumatic diseases and healthy subjects. The cutoff with the best diagnostic performance was determined by the Youden Index and receiver operating characteristic analysis<\/jats:p>\n                    <jats:p>Results: Three hundred and thirty\u2010two serum samples were analysed. The cutoffs proposed in our population were for RF in RA patients versus other rheumatic diseases, and healthy subjects IgM 135 IU\/mL, for each disease, compared with RA, were psoriatic arthritis (Psa) IgA 47.2 IU\/mL, clinically suspicious arthralgia (CSA) IgA 39.5 IU\/mL, primary Sj\u00f6gren's syndrome (pSS) IgM 180.6 IU\/mL, systemic lupus erythematosus (SLE) IgA 42.6 IU\/mL, primary fibromyalgia (pFM) IgM 68.6 IU\/mL, osteoarthritis (OA) IgM 48 IU\/mL, gout IgM 117 IU\/mL and healthy IgM 16.3 IU\/mL. For anti\u2010CCP, in RA patients versus other rheumatic diseases, and healthy subjects 6.95 IU\/mL, for each disease, compared with RA, were Psa 6.8 IU\/mL, CSA 9.95 IU\/mL, pSS 20.7 IU\/mL, SLE 6 IU \/mL, pFM 11.8 IU\/mL, OA 11.9 IU\/mL, gout 5 IU\/mL and healthy 5 IU\/mL.<\/jats:p>\n                    <jats:p>Conclusion: Irrespective of the manufacturer's suggested cutoff, the RA versus differential diagnosis cutoffs must be considered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/iji.12643","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T02:55:41Z","timestamp":1699325741000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Are the cut\u2010offs of the rheumatoid factor and anti\u2010cyclic citrullinated peptide antibody different to distinguish rheumatoid arthritis from their primary differential diagnoses?"],"prefix":"10.1111","volume":"51","author":[{"given":"Rita Ang\u00e9lica","family":"Pineda\u2010Sic","sequence":"first","affiliation":[{"name":"Rheumatology Department Universidad Autonoma de Nuevo Leon  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0651-2202","authenticated-orcid":false,"given":"David","family":"Vega\u2010Morales","sequence":"additional","affiliation":[{"name":"Rheumatology Department Universidad Autonoma de Nuevo Leon  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"Santoyo\u2010Fexas","sequence":"additional","affiliation":[{"name":"Rheumatology Department Universidad Autonoma de Nuevo Leon  Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Alberto","family":"Garza\u2010Elizondo","sequence":"additional","affiliation":[{"name":"Rheumatology Department Universidad Autonoma de Nuevo Leon  Monterrey 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