{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:16:20Z","timestamp":1747185380307,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8230041447","82171040","82301271","82101108"],"award-info":[{"award-number":["8230041447","82171040","82301271","82101108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genome\u2010wide association studies analysis has revealed associations between ankylosing spondylitis (AS) and loci on the <jats:italic>TBX21<\/jats:italic> gene across various populations. This study aimed to investigate if there is a connection between a higher risk of AS in a Chinese population and two polymorphism loci on the <jats:italic>TBX21<\/jats:italic> gene. To achieve this, we performed a case\u2013control investigation involving 363 patients with AS and 907 healthy individuals. Genotyping was carried out using the iPLEX Gold genotyping assay. The analysis of genotypes and haplotypes was performed using SPSS 23.0 and SHEsis software. The results revealed no statistically significant correlation between the two specified single\u2010nucleotide polymorphisms of <jats:italic>TBX21<\/jats:italic> (rs11657479 C\/T and rs4794067 C\/T) and susceptibility to AS. However, upon conducting stratification analysis, our findings demonstrated a significant association between rs11657479 and susceptibility to human leucocyte antigen (HLA)\u2010B27<jats:sup>+<\/jats:sup> AS in allelic (C vs. T: odds ratio [OR]\u00a0=\u00a01.52, 95%CI\u00a0=\u00a01.09\u20132.11, corrected <jats:italic>p<\/jats:italic> [pc]\u00a0=\u00a0.028), heterozygous (CT vs. TT: OR\u00a0=\u00a01.63, 95%CI\u00a0=\u00a01.13\u20132.34, pc\u00a0=\u00a0.016) and dominant (CT\u00a0+\u00a0CC vs. TT: OR\u00a0=\u00a01.60, 95%CI\u00a0=\u00a01.12\u20132.28, pc\u00a0=\u00a0.018) models. Furthermore, the haplotype rs4794067\/C\u2010rs11657479\/C of <jats:italic>TBX21<\/jats:italic> was found to increase the risk of HLA\u2010B27<jats:sup>+<\/jats:sup> AS cases. In conclusion, our findings indicate a correlation between <jats:italic>TBX21<\/jats:italic> gene polymorphism and HLA\u2010B27<jats:sup>+<\/jats:sup> AS patients within the Chinese population.<\/jats:p>","DOI":"10.1111\/iji.12659","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T06:09:23Z","timestamp":1710223763000},"page":"143-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of TBX21 gene polymorphisms with ankylosing spondylitis in a Chinese population"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1659-7794","authenticated-orcid":false,"given":"Lin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiankang","family":"Shan","sequence":"additional","affiliation":[{"name":"The Academy of Medical Sciences, Zhengzhou University Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixin","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangqi","family":"An","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair Zhengzhou P. R. China"},{"name":"The Academy of Medical Sciences, Zhengzhou University Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Academy of Medical Sciences, Zhengzhou University Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunpeng","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuemin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peizeng","family":"Yang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology The First Affiliated Hospital of Zhengzhou University, Henan Province Eye Hospital, Henan International Joint Research Laboratory for Ocular Immunology and Retinal Injury Repair Zhengzhou P. R. 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