{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:52:37Z","timestamp":1782921157525,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The autophagy gene immunity\u2010related GTPase M (<jats:italic>IRGM<\/jats:italic>) can affect the immune response against intracellular pathogens. The study was performed to determine any possible association between three <jats:italic>IRGM<\/jats:italic> single\u2010nucleotide polymorphisms (SNPs) (rs4958842, rs4958843 and rs4958846) and chronic hepatitis B virus (HBV) infection. A total of 171 chronic HBV\u2010infected individuals and 171 healthy controls were collected. Peripheral blood cells and Sanger sequencing were used to extract genomic DNA and determine the SNP genotypes, respectively. The C allele of rs4958843 is a risk factor for chronic HBV infection in various genetic models, including allelic, codominant and dominant models, with the following respective statistical data: allelic (T vs. C: OR\u00a0=\u00a01.371, 95% CI\u00a0=\u00a01.009\u20131.863, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.043), codominant (TT vs. CC: OR\u00a0=\u00a02.137, 95% CI\u00a0=\u00a01.104\u20134.138, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.024) and dominant (TT\u00a0+\u00a0TC vs. CC: OR\u00a0=\u00a01.976, 95% CI\u00a0=\u00a01.106\u20133.533, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.021) models. The genotype and allele distributions of rs4958842 and rs4958846 showed no significant differences between chronic HBV infection patients and healthy controls. <jats:italic>IRGM<\/jats:italic> rs4958843 CC genotype carriers had significantly elevated values of alanine transaminase, aspartate transaminase alpha\u2010fetoprotein and total bilirubin (OR\u00a0=\u00a03.467, 95%CI\u00a0=\u00a01.167\u201310.298), which was positively associated with the disease progression of HBV infection. Mutant allele C of <jats:italic>IRGM<\/jats:italic> rs4958843 polymorphism is associated with the risk of chronic HBV infection in the Han people in central China and contributes to the disease progression.<\/jats:p>","DOI":"10.1111\/iji.12661","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T04:28:37Z","timestamp":1711081717000},"page":"149-156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of <i>IRGM<\/i> gene promoter polymorphisms on susceptibility to chronic HBV infection"],"prefix":"10.1111","volume":"51","author":[{"given":"Hai","family":"Cheng","sequence":"first","affiliation":[{"name":"School of Medicine &amp; Health Sciences Jingzhou University  Jingzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoling","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Jingzhou Hospital Affiliated to Yangtze University  Jingzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1683-309X","authenticated-orcid":false,"given":"Chengbin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Jingzhou Hospital Affiliated to Yangtze University  Jingzhou 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