{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T03:27:26Z","timestamp":1782617246989,"version":"3.54.5"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human leukocyte antigens (HLA) represent one of the most polymorphic systems in humans, responsible for the identification of foreign antigens and the presentation of immune responses. Therefore, HLA is considered to play a major role in human disorders, donor\u2010recipient matching and transplantation outcomes. This study aimed to determine the HLA class I and II alleles and haplotypes in the Greek population. Moreover, a comparative analysis of HLA alleles and haplotype frequencies found in Greek and pooled European populations was also performed to acquire a better knowledge about the HLA alleles distribution. A total number of 1896 healthy individuals were typed for their HLA alleles in the National Tissue Typing Center of Greece. High\u2010resolution HLA typing for the HLA\u2010A, \u2010B, \u2010C and \u2010DR, \u2010DQ, \u2010DP with the use of the next\u2010generation sequencing analysis was performed, followed by data analysis for establishing the HLA allele and haplotype differences. The results of this study showed that the most frequent alleles for the HLA\u2010A were the A*02:01:01 (27.1%), *24:02:01 (14.4%), *01:01:01 (9.3%), for the HLA\u2010B were the B*51:01:01 (15.3%), *18:01:01 (9.7%), *35:01:01 (6.8%) and for the HLA\u2010C were the C*04:01:01 (15.4%), *07:01:01 (13.1%), *12:03:01 (9.6%). For the HLA class II, the most frequent alleles for the HLA\u2010DRB1 were the DRB1*11:04:01 (16.4%), *16:01:01 (11.3%), *11:01:01 (9.5%), for the HLA\u2010DQB1 were the DQB1*03:01:01 (30.5%), *05:02:01 (15.1%), *05:01:01 (10.6%) and for the HLA\u2010DPB1 were the DPB1*04:01:01 (34.8%), *02:01:01 (11.6%), *04:02:01 (7.3%). Additionally, the most frequent haplotypes were the A*02:01:01\u223cC*07:01:01\u2010B*18:01:01\u223cDRB1*11:04:01 (2.3%), followed by the A*01:01:01\u223cC*07:01:01\u223cB*08:01:01\u223cDRB1*03:01:01 (2.2%), A*24:02:01\u223cC*04:01:01\u223cB*35:02:01\u223cDRB1*11:04:01 (1.4%) and A*02:01:01\u223cC*04:01:01\u223cB*35:01:01\u2010DRB1*14:01:01 (1.2%). The results herein were comparable to those obtained from the pooled European populations. Moreover, these results can be used for the improvement of the donor\u2010recipient matching procedure and to understand better the disease association in Greece.<\/jats:p>","DOI":"10.1111\/iji.12663","type":"journal-article","created":{"date-parts":[[2024,3,9]],"date-time":"2024-03-09T04:20:00Z","timestamp":1709958000000},"page":"164-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Frequency distribution of HLA class I and II alleles in Greek population and their significance in orchestrating the National Donor Registry Program"],"prefix":"10.1111","volume":"51","author":[{"given":"Panagiotis","family":"Mallis","sequence":"first","affiliation":[{"name":"Immunology Department &amp; National Tissue Typing Center General Hospital of Athens \u201cG. Gennimatas\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Siorenta","sequence":"additional","affiliation":[{"name":"Immunology Department &amp; National Tissue Typing Center General Hospital of Athens \u201cG. Gennimatas\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erasmia","family":"Stamathioudaki","sequence":"additional","affiliation":[{"name":"Immunology Department &amp; National Tissue Typing Center General Hospital of Athens \u201cG. Gennimatas\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Vrani","sequence":"additional","affiliation":[{"name":"Immunology Department &amp; National Tissue Typing Center General Hospital of Athens \u201cG. Gennimatas\u201d  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Paterakis","sequence":"additional","affiliation":[{"name":"Immunology Department &amp; National Tissue Typing Center General Hospital of Athens \u201cG. 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