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Inflammatory cytokines and chemokines secreted by activated immunocytes can trigger various inflammatory and immune responses in articular cartilage and synovium, contributing to the genesis and development of OA. A series of monocyte\/macrophage chemokines, including monocyte chemotaxis protein (MCP)\u20101\/CCL2, MCP2\/CCL8, macrophage inflammatory protein (MIP)\u20101\u03b1\/CCL3, MIP\u20101\u03b2\/CCL4, MIP\u20103\u03b1\/CCL20, regulated upon activation, normal T\u2010cell expressed and secreted \/CCL5, CCL17 and macrophage\u2010derived chemokine\/CCL22, was proven to transmit cell signals by binding to G protein\u2013coupled receptors on recipient cell surface, mediating and promoting inflammation in OA joints. However, the underlying mechanism of these chemokines in the pathogenesis of OA remains still elusive. Here, published literature was reviewed, and the function and mechanisms of monocyte\/macrophage chemokines in OA pathogenesis were summarised. The symptoms and disease progression of OA were found to be effectively alleviated when the expression of these chemokines is inhibited. Elucidating these mechanisms could contribute to further understand how OA develops and provide potential targets for the early diagnosis of arthritis and drug treatment to delay or even halt OA progression.<\/jats:p>","DOI":"10.1111\/iji.12664","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T03:53:52Z","timestamp":1710129232000},"page":"130-142","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["The role of monocyte\/macrophage chemokines in pathogenesis of osteoarthritis: A review"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1077-3747","authenticated-orcid":false,"given":"Hao","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Orthopaedics The People's Hospital Affiliated to Jiangsu University Zhenjiang Jiangsu 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