{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T07:08:51Z","timestamp":1773472131736,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Carriage of HLA\u2010DQA1*05 is thought to increase the formation of anti\u2010tumour necrosis factor alpha (TNF\u2010\u03b1) antibodies, reducing the drug efficacy in Crohn's disease (CD) patients. However, little data are currently available for small\u2010bowel Crohn's disease (SB\u2010CD). A specific assessment of the impact of HLA\u2010DQA1*05 on the clinical response to treatment with infliximab (IFX), a TNF\u2010\u03b1 antagonists, in SB\u2010CD patients is necessary. We conducted a single\u2010center retrospective study that included 106 SB\u2010CD patients treated with IFX. The serum samples were collected for antibodies to infliximab (ATI) testing and HLA\u2010DQA1*05 genotyping. Double\u2010balloon enteroscopy (DBE) was performed following the IFX treatment, with endoscopic outcomes evaluated using the partial simple endoscopic score for CD (pSES\u2010CD), whereas the clinical response was assessed with the Crohn's disease activity index (CDAI). Multivariate logistic regression and multivariate COX regression analyses were employed to analyze the correlation of the HLA\u2010DQA1*05 genotypes with other clinical variables. In this study, 30.2% of SB\u2010CD patients carried the HLA\u2010DQA1*05 allele, which significantly increased their risk of ATI generation (odds ratio [OR]\u00a0=\u00a02.337, p\u00a0=\u00a0.043), but it was not associated with the clinical response to IFX and drug persistence (OR\u00a0=\u00a02.356, p\u00a0=\u00a0.145; OR\u00a0=\u00a00.457, p\u00a0=\u00a0.249). The endoscopic remission rates were 40.6% (13\/32) and 55.4% (41\/74) in HLA\u2010DQA1*05 carriers and non\u2010carriers, respectively. HLA\u2010DQA1*05 was not associated with endoscopic remission (OR\u00a0=\u00a00.684, p\u00a0=\u00a0.414). The HLA\u2010DQA1*05 variant is identified as a significant risk factor of ATI formation in Chinese patients with SB\u2010CD, but is not associated with the clinical response of IFX treatment and endoscopic remission of SB lesions.<\/jats:p>","DOI":"10.1111\/iji.12696","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T08:48:55Z","timestamp":1728550135000},"page":"380-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Does HLA\u2010DQA1*05 carriage have a greater impact on the outcome of infliximab therapy for isolated small\u2010bowel Crohn's disease?"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6973-4641","authenticated-orcid":false,"given":"Juan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nannan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongrong","family":"Shi","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0635-6564","authenticated-orcid":false,"given":"Qiao","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7591-6801","authenticated-orcid":false,"given":"Bingqing","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1848-6305","authenticated-orcid":false,"given":"Wei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Anhui Medical University Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.08.035"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32413"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365\u20102036.2003.01574.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575\u2010021\u201000424\u20106"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020888"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl\u20102022\u2010328052"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001396"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102036.2011.04598.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602773"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izac259"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjw168"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(02)08512\u20104"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003348"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262\u2010017\u20100627\u20100"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000001202"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjy146"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco\u2010jcc\/jjv096"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1423\u20100127\u201019\u201088"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izad130"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.579"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.233"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2010.70"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.02.072"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.09.041"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2020.01.008"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(21)00312\u20105"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.03.044"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.01.009"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16551"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(16)31711\u20101"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15563"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1096816"}],"container-title":["International Journal of Immunogenetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/iji.12696","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/iji.12696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T06:31:33Z","timestamp":1773469893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/iji.12696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1111\/iji.12696"],"URL":"https:\/\/doi.org\/10.1111\/iji.12696","archive":["Portico"],"relation":{},"ISSN":["1744-3121","1744-313X"],"issn-type":[{"value":"1744-3121","type":"print"},{"value":"1744-313X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]},"assertion":[{"value":"2024-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}