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The majority of infection cases are classified as uncomplicated malaria, causing mild symptoms such as fever and headache. However, the disease may progress to severe malaria and death if the infection is not properly treated. Furthermore, malaria poses a major concern for children, pregnant women and immunosuppressed individuals. Exacerbated inflammation is characteristic of severe malaria cases. The C\u2013C chemokine receptor type 5 (CCR5) is an important molecule for leukocyte migration and regulation of inflammation. Although widely known as an HIV\u20101 co\u2010receptor, CCR5 also affects the susceptibility and progression of autoimmune and inflammatory diseases. There is evidence supporting the participation of CCR5 in malaria manifestations, with the evaluation of\n                    <jats:italic>CCR5<\/jats:italic>\n                    gene expression levels suggested as a marker to monitor malaria severity. Certain genetic variants in the\n                    <jats:italic>CCR5<\/jats:italic>\n                    gene affect CCR5 expression, potentially altering CCR5\u2010mediated inflammatory responses during malaria infection. However, the complex influences of CCR5 on malaria remain underexplored. 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