{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T05:18:58Z","timestamp":1737523138999,"version":"3.33.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:label\/><jats:p>This study sought to investigate the association between <jats:italic>interleukin\u201010<\/jats:italic> (<jats:italic>IL10<\/jats:italic>) polymorphisms and susceptibility to Sj\u00f6gren's syndrome. A systematic search of the Medline, Embase and Web of Science databases was conducted to identify relevant articles from inception to April 2024. No restrictions were placed on race, ethnicity or geographic area, but only studies published in English were included. A meta\u2010analysis was conducted to evaluate the association among the <jats:italic>IL10<\/jats:italic>\u20101082 G\/A (rs1800896), \u2010819 C\/T (rs1800871) and \u2010592 C\/A (rs1800872) polymorphisms, as well as their haplotypes and the risk of developing Sj\u00f6gren's syndrome. The included studies involved 998 Sj\u00f6gren's syndrome patients and 1576 controls. Ten studies were included in the meta\u2010analysis. Meta\u2010analysis of the <jats:italic>IL10<\/jats:italic>\u20101082 G\/A polymorphism revealed no significant association with Sj\u00f6gren's syndrome (odds ratio [OR]\u00a0=\u00a01.115, 95% confidence interval [CI]: 0.888\u20131.401, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.343), with stratification by ethnicity yielding consistent results for Europeans and Latin Americans. Similarly, the <jats:italic>IL10<\/jats:italic>\u2010819 C\/T polymorphism was not associated with Sj\u00f6gren's syndrome in any study subjects (OR\u00a0=\u00a00.859, 95% CI: 0.648\u20131.138, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.290). The <jats:italic>IL10<\/jats:italic>\u2010592 C allele also exhibited no association with Sj\u00f6gren's syndrome (OR\u00a0=\u00a01.131, 95% CI: 0.776\u20131.646, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.522). However, the GCC carrier status demonstrated a significant association with Sj\u00f6gren's syndrome across all study subjects (OR\u00a0=\u00a01.496, 95% CI: 1.200\u20131.865, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001), particularly in Europeans (OR\u00a0=\u00a01.444, 95% CI: 1.085\u20131.921, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012) and Latin Americans (OR\u00a0=\u00a01.324, 95% CI: 1.115\u20132.366, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.012). A significant protective effect of the homozygous ATA\/ATA haplotype on Sj\u00f6gren's syndrome was found in Europeans (OR\u00a0=\u00a00.320, 95% CI: 0.121\u20130.846, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.022).<\/jats:p><\/jats:sec><jats:sec><jats:label\/><jats:p>This meta\u2010analysis indicates a significant link between carrying the GCC haplotype of the <jats:italic>IL10<\/jats:italic>\u20101082 G\/A, \u2010819 C\/T and \u2010592 C\/A polymorphisms and an increased susceptibility to Sj\u00f6gren's syndrome. Conversely, the homozygous ATA\/ATA haplotype appears to confer protection against the risk of Sj\u00f6gren's syndrome, particularly in European populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/iji.12702","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T07:39:33Z","timestamp":1731051573000},"page":"24-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between <i>Interleukin\u201010<\/i> Polymorphisms and Susceptibility to Sj\u00f6gren's Syndrome: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4213-1909","authenticated-orcid":false,"given":"Young Ho","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Rheumatology Korea University Anam Hospital Korea University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwan Gyu","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Korea University Anam Hospital Korea University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.4078\/jrd.2023.0021"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.47"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7682827"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197\u20102456(86)90046\u20102"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12149"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7121.1533"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20100039.1997.tb02812.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.9.1025"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20060"},{"issue":"2","key":"e_1_2_8_12_1","first-page":"154","article-title":"Analysis of Single Nucleotide Polymorphisms in the Promoter Region of Interleukin\u201010 by Denaturing High\u2010performance Liquid Chromatography","volume":"16","author":"Guzowski D.","year":"2005","journal-title":"Journal of Biomolecular Techniques"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200101)44:1<176::AID-ANR23>3.0.CO;2-K"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4078\/jrd.2023.0002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2015.35.3.283"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.195"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010011\u20100712\u20107"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.4078\/jrd.2023.0005"},{"key":"e_1_2_8_20_1","first-page":"1","volume-title":"The Genetic Dissection of the Autoimmune Diseases Systemic Lupus Erythematosus and Sj\u00f6gren's Syndrome","author":"Lessard C. 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