{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T04:10:33Z","timestamp":1741839033335,"version":"3.38.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Background and Aims: Genetic factors, including polymorphisms in the\u00a0<jats:italic>TNFRSF13B<\/jats:italic>\u00a0gene, which regulates humoral immunity, can influence susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102). This study aims to investigate the association between two polymorphisms, rs12603708 and rs3751987, and SARS\u2010CoV\u20102 susceptibility, disease severity, and humoral immune responses in a Moroccan population.<\/jats:p><jats:p>Materials and Methods: A total of 303 unvaccinated COVID\u201019 patients (151 severe cases and 152 asymptomatic\/moderate cases) and 150 individuals from a SARS\u2010CoV\u20102\u2010negative group were included in the analysis. Genotyping was performed using TaqMan SNP assays. SARS\u2010CoV\u20102 antibodies targeting the nucleocapsid protein and IgG antibodies specific to the receptor\u2010binding domain (RBD) were quantified using chemiluminescence microparticles immunoassay. Complete blood counts and C\u2010reactive protein levels were evaluated using an automated platform.<\/jats:p><jats:p>Results: Our analysis revealed that the A\/A genotype of rs12603708 significantly increased the risk of SARS\u2010CoV\u20102 infection in both codominant (<jats:italic>p<\/jats:italic> = 0.0055; OR = 3.74; adjusted <jats:italic>p<\/jats:italic> value = 0.022) and recessive (<jats:italic>p<\/jats:italic> = 0.0049; OR = 3.17; adjusted <jats:italic>p<\/jats:italic> value = 0.022) models, as well as the risk of severe disease (<jats:italic>p<\/jats:italic> = 0.014; OR = 3.43; adjusted <jats:italic>p<\/jats:italic> value = 0.049). For rs3751987, the G\/G genotype was linked to higher susceptibility to infection (<jats:italic>p<\/jats:italic> = 0.0011; OR = 2.91; adjusted <jats:italic>p<\/jats:italic> value = 0.008), while the G\/A genotype appeared protective (<jats:italic>p<\/jats:italic> = 0.0007; OR = 0.45; adjusted <jats:italic>p<\/jats:italic> value = 0.008). No association was found between rs3751987 and disease severity. Analysis of IgG anti\u2010N and anti\u2010RBD levels revealed no significant associations with either polymorphism (<jats:italic>p<\/jats:italic> &gt;\u00a00.05).<\/jats:p><jats:p>Conclusion: These findings highlight the role of\u00a0<jats:italic>TNFRSF13B<\/jats:italic>\u00a0polymorphisms in SARS\u2010CoV\u20102 susceptibility and severity, while their impact on humoral immune responses appears limited.<\/jats:p>","DOI":"10.1111\/iji.12709","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T08:33:38Z","timestamp":1741422818000},"page":"75-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of <i>TNFRSF13B<\/i> Gene Polymorphisms With SARS\u2010CoV\u20102 Infection, Severity, and Humoral Immune Response in a Moroccan Population"],"prefix":"10.1111","volume":"52","author":[{"given":"Oumaima","family":"Laazaazia","sequence":"first","affiliation":[{"name":"Virology Unit Viral Hepatitis Laboratory Institut Pasteur du Maroc  Casablanca Morocco"},{"name":"Laboratory of Virology, Microbiology Quality and Biotechnology\/Ecotoxicology and Biodiversity Hassan II University, Facult\u00e9 des Sciences et Techniques  Mohammedia Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahd","family":"Ouladlahsen","sequence":"additional","affiliation":[{"name":"Service des maladies Infectieuses, CHU Ibn Rochd  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Safaa","family":"Aqillouch","sequence":"additional","affiliation":[{"name":"Virology Unit Viral Hepatitis Laboratory Institut Pasteur du Maroc  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haya","family":"Altawalah","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Medicine Kuwait University  Safat Kuwait"},{"name":"Virology Unit Yacoub Behbehani Center Sabah Hospital, Ministry of Health  Shuwaikh Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oumaima","family":"Bouddahab","sequence":"additional","affiliation":[{"name":"Virology Unit Viral Hepatitis Laboratory Institut Pasteur du Maroc  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachid","family":"Noureddine","sequence":"additional","affiliation":[{"name":"Virology Unit Viral Hepatitis Laboratory Institut Pasteur du Maroc  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal","family":"Pineau","sequence":"additional","affiliation":[{"name":"Institut Pasteur Universit\u00e9 Paris Cit\u00e9, Unit\u00e9 \u00ab Organisation Nucl\u00e9aire et Oncogen\u00e8se\u00bb, INSERM U993  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustapha","family":"Lkhider","sequence":"additional","affiliation":[{"name":"Laboratory of Virology, Microbiology Quality and Biotechnology\/Ecotoxicology and Biodiversity Hassan II University, Facult\u00e9 des Sciences et Techniques  Mohammedia Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3982-6163","authenticated-orcid":false,"given":"Sayeh","family":"Ezzikouri","sequence":"additional","affiliation":[{"name":"Virology Unit Viral Hepatitis Laboratory Institut Pasteur du Maroc  Casablanca Morocco"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11081919"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12091425"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.10.006"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.634544"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1601"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(20)30211\u20107"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.150483"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12920\u2010023\u201001793\u20104"},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","unstructured":"Ezzikouri S. 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