{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T04:08:28Z","timestamp":1747714108024,"version":"3.40.5"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100015027","name":"Vice Chancellor for Research and Technology, Hamadan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The present study aimed to determine the association of <jats:italic>HLA\u2010DRB1\/\u2010DQB1<\/jats:italic> alleles with response to treatment and anti\u2010citrullinated peptide antibody (ACPA) status in Iranian rheumatoid arthritis (RA) patients. A total of 167 RA patients, including 114 good responders (GRs) and 53 poor responders (PRs) as well as 330 ethnic\u2010matched healthy controls, participated in this study. Disease activity and treatment response were assessed using the Disease Activity Score 28\u2010joint (DAS28) scores during the 9\u2010month post\u2010treatment. <jats:italic>HLA\u2010DRB1\/\u2010DQB1<\/jats:italic> alleles were identified using polymerase chain reaction with a sequence\u2010specific primers (PCR\u2010SSP) method and compared between the study groups. Of the patients, 106 (63.5%) were ACPA\u2010positive, 88 (52.7%) human leucocyte antigen (<jats:italic>HLA<\/jats:italic>)\u2010shared epitope (<jats:italic>SE<\/jats:italic>)\u2010positive, 64 (38.3%) ACPA+<jats:italic>SE<\/jats:italic>+ and 37 (22.2%) ACPA\u2212<jats:italic>SE<\/jats:italic>\u2212. <jats:italic>HLA\u2010SE<\/jats:italic> alleles were significantly more frequent in patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a03.2e\u00a0\u2212\u00a005), in PR versus GR patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01) and in ACPA+ versus ACPA\u2212 patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.009). PR patients had a higher prevalence of ACPA+<jats:italic>SE<\/jats:italic>+ compared to GR patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.02). Higher frequencies of <jats:italic>DRB1*04:02<\/jats:italic> (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>\u00a0=\u00a00.03), <jats:italic>*04:04<\/jats:italic> (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>\u00a0=\u00a00.007), <jats:italic>*04:05<\/jats:italic> (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>\u00a0=\u00a05.0e\u00a0\u2212\u00a005), *<jats:italic>10:01<\/jats:italic> (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>\u00a0=\u00a01.0e\u00a0\u2212\u00a004), <jats:italic>DQB1*03:02<\/jats:italic> (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>\u00a0=\u00a00.002) and <jats:italic>*05:01<\/jats:italic> (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>\u00a0=\u00a00.002) alleles, and lower frequencies of <jats:italic>DRB1*04:01<\/jats:italic> (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>\u00a0=\u00a00.007), <jats:italic>*11:01<\/jats:italic> (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>\u00a0=\u00a00.03), <jats:italic>*13:01<\/jats:italic> (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>\u00a0=\u00a00.03) and <jats:italic>DQB1*06:03<\/jats:italic> (<jats:italic>p<\/jats:italic><jats:sub>c<\/jats:sub>\u00a0=\u00a00.03) alleles were observed in patients compared to healthy controls. These findings suggest a relationship between <jats:italic>HLA\u2010SE<\/jats:italic> alleles and ACPA development and a potential link between <jats:italic>HLA\u2010SE<\/jats:italic>\/non\u2010<jats:italic>SE<\/jats:italic> alleles and therapeutic responses in RA patients.<\/jats:p>","DOI":"10.1111\/iji.12711","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T07:46:40Z","timestamp":1744098400000},"page":"141-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Potential Link Between <i>HLA\u2010DRB1\/DQB1<\/i> Alleles and Response to Treatment in Rheumatoid Arthritis Patients"],"prefix":"10.1111","volume":"52","author":[{"given":"Ahmad","family":"Tahamoli\u2010Roudsari","sequence":"first","affiliation":[{"name":"Department of Internal Diseases Medicine, School of Medicine Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashkan","family":"Rasouli\u2010Saravani","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Basiri","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases Medicine, School of Medicine Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrdad","family":"Hajilooi","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Hamadan University of Medical Sciences Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8929-5658","authenticated-orcid":false,"given":"Ghasem","family":"Solgi","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Hamadan University of Medical Sciences Hamadan Iran"},{"name":"Cancer Research Center, Institute of Cancer Avicenna Health Research Institute Hamadan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1016\/j.autrev.2004.09.002"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1136\/ard.2010.138461"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.3389\/fimmu.2023.1178546"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1016\/j.humimm.2020.02.008"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1002\/art.21391"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1371\/journal.pone.0245541"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1016\/S0889-857X(03)00069-3"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1002\/art.1780301102"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.4049\/jimmunol.171.2.538"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1186\/s13075-021-02612-w"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1002\/art.23166"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1002\/art.21385"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1007\/s00251-017-0987-5"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.1038\/nrrheum.2010.23"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.1111\/tan.12855"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.1136\/ard.2003.009969"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.1002\/art.34421"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.1002\/art.37814"},{"issue":"4","key":"e_1_2_10_20_1","first-page":"674","article-title":"Influence of HLADRB1 Genes and the Shared Epitope on Genetic Susceptibility to Rheumatoid Arthritis in Taiwanese","volume":"34","author":"Liu S. 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