{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:27:54Z","timestamp":1768559274947,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Immunogenetics"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Some associations between <jats:italic>Treponema pallidum<\/jats:italic> (TP) susceptibility and human leukocyte antigen <jats:italic>(HLA)<\/jats:italic> loci at low resolution have been reported. However, the data for TP infection and <jats:italic>HLA<\/jats:italic> alleles at high resolution are limited. The purpose of this study was to perform a high\u2010resolution screen for <jats:italic>HLA<\/jats:italic> alleles that confer susceptibility to TP infection in the Chinese Han population. A total of 184 individuals with TP infection were included in the study, and 254 unrelated healthy blood donors were included in the control group. The samples were genotyped for the <jats:italic>HLA\u2010A, \u2010C, \u2010B, \u2010DRB1, \u2010DQB1<\/jats:italic> and <jats:italic>\u2010DPB1<\/jats:italic> loci using next\u2010generation sequencing (NGS) technology. The correlations between TP infection and the alleles and haplotypes of <jats:italic>HLA<\/jats:italic> loci were determined by statistical analysis. Five <jats:italic>HLA<\/jats:italic> alleles, including <jats:italic>HLA\u2010A*32:01<\/jats:italic> (0.00% vs. 1.57%, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.024), <jats:italic>\u2010B*52:01<\/jats:italic> (1.36% vs. 4.13%, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.025), <jats:italic>\u2010C*01:02<\/jats:italic> (22.55% vs. 16.54%, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.029), <jats:italic>\u2010C*04:03<\/jats:italic> (1.63% vs. 0.2%, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.046) and <jats:italic>\u2010DQB1*05:03<\/jats:italic> (1.63% vs. 4.13%, <jats:italic>p\u00a0<\/jats:italic>=\u00a00.046), are potentially associated with TP infection. However, no significant difference was detected after <jats:italic>p<\/jats:italic> value correction. The frequency of the <jats:italic>HLA\u2010A*33:03\u2010C*03:02\u2010B*58:01\u2010DRB1*03:01\u2010DQB1*02:01\u2010DPB1*05:01<\/jats:italic> haplotype in the control group was greater than that in the TP infection group (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.002). In contrast, the frequency of the <jats:italic>HLA\u2010A*02:07\u2010C*01:02\u2010B*46:01\u2010DRB1*08:03\u2010DQB1*06:01\u2010DPB1*02:01<\/jats:italic>, <jats:italic>HLA\u2010A*11:01\u2010C*03:04\u2010B*13:01\u2010DRB1*09:01\u2010DQB1*03:03\u2010DPB1*05:01<\/jats:italic>, <jats:italic>HLA\u2010A*11:01\u2010C*07:02\u2010B*40:01\u2010DRB1*08:03\u2010DQB1*06:01\u2010DPB1*02:01<\/jats:italic> and <jats:italic>HLA\u2010A*30:01\u2010C*06:02\u2010B*13:02\u2010DRB1*07:01\u2010DQB1*02:02\u2010DPB1*02:01<\/jats:italic> haplotypes were lower in the control group than in the TP infection group (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.05). <jats:italic>HLA\u2010C*01:02<\/jats:italic> and <jats:italic>\u2010C*04:03<\/jats:italic> may confer susceptibility to TP infection, whereas <jats:italic>A*32:01<\/jats:italic>, <jats:italic>\u2010B*52:01<\/jats:italic> and <jats:italic>\u2010DQB1*05:03<\/jats:italic> may protect against TP infection. These data are helpful in preventing and controlling TP transmission.<\/jats:p>","DOI":"10.1111\/iji.12716","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T23:28:01Z","timestamp":1747178881000},"page":"189-194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>HLA\u2010C*01:02<\/i> and <i>\u2010C*04:03<\/i> May Confer Susceptibility to <i>Treponema pallidum<\/i> Infection in the Chinese Han Population"],"prefix":"10.1111","volume":"52","author":[{"given":"Chen","family":"Chen","sequence":"first","affiliation":[{"name":"HLA Typing Laboratory Blood Center of Zhejiang Province  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory Blood Center of Zhejiang Province  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanying","family":"Chen","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory Blood Center of Zhejiang Province  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Dong","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory Blood Center of Zhejiang Province  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory Blood Center of Zhejiang Province  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"He","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory Blood Center of Zhejiang Province  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faming","family":"Zhu","sequence":"additional","affiliation":[{"name":"HLA Typing Laboratory Blood 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